Title:
4’-C-CYANO-2’-DEOXYPURINE NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO/2003/068796
Kind Code:
A1
Abstract:
4’-C-Cyano-2’-deoxypurine nucleosides represented by the following general formula [I] which have an excellent anti-HIV effect, in particular, an efficacy on multidrug-resistant HIV strains having resistance to a plural number of anti-HIV drugs such as AZT, ddI, ddC, d4T and 3TC without causing any problems in cytotoxicity; and medicinal compositions comprising such a compound and a pharmaceutically acceptable carrier: [I] wherein B represents a purine base; and R represents hydrogen or phosphate.
Inventors:
KOHGO SATORU (JP)
YAMADA KOHEI (JP)
SAKATA SHINJI (JP)
OHRUI HIROSHI (JP)
KODAMA EIICHI (JP)
MATSUOKA MASAO (JP)
MITSUYA HIROAKI (JP)
YAMADA KOHEI (JP)
SAKATA SHINJI (JP)
OHRUI HIROSHI (JP)
KODAMA EIICHI (JP)
MATSUOKA MASAO (JP)
MITSUYA HIROAKI (JP)
Application Number:
PCT/JP2003/001218
Publication Date:
August 21, 2003
Filing Date:
February 06, 2003
Export Citation:
Assignee:
YAMASA CORP (JP)
KOHGO SATORU (JP)
YAMADA KOHEI (JP)
SAKATA SHINJI (JP)
OHRUI HIROSHI (JP)
KODAMA EIICHI (JP)
MATSUOKA MASAO (JP)
MITSUYA HIROAKI (JP)
KOHGO SATORU (JP)
YAMADA KOHEI (JP)
SAKATA SHINJI (JP)
OHRUI HIROSHI (JP)
KODAMA EIICHI (JP)
MATSUOKA MASAO (JP)
MITSUYA HIROAKI (JP)
International Classes:
A61P31/18; C07H19/04; (IPC1-7): C07H19/173; A61K31/7076; A61P31/18
Domestic Patent References:
| WO2000069877A1 | 2000-11-23 | |||
| WO2002100415A2 | 2002-12-19 |
Foreign References:
| US5192749A | 1993-03-09 |
Other References:
O-YANG COUNDE ET AL.: "Synthesis of 4'-cyanothymidine and analogs as potent inhibitors of HIV", TETRAHEDRON LETTERS, vol. 33, no. 1, 1 January 1992 (1992-01-01), pages 37 - 40, XP002969549
NOMURA MAKOTO ET AL.: "Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'-alpha-C-branched-chain sugar pyrimidine nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 15, 29 July 1999 (1999-07-29), pages 2901 - 2908, XP000915083
ESTRADA ERNESTO ET AL.: "In silico studies toward the discovery of new anti-HIV nucleoside compounds with the use of TOPS-MODE and 2D/3D connectivity indices. 1. Pyrimidyl derivatives", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, vol. 42, no. 5, 2002, pages 1194 - 1203, XP002969550
NOMURA MAKOTO ET AL.: "Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'-alpha-C-branched-chain sugar pyrimidine nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 15, 29 July 1999 (1999-07-29), pages 2901 - 2908, XP000915083
ESTRADA ERNESTO ET AL.: "In silico studies toward the discovery of new anti-HIV nucleoside compounds with the use of TOPS-MODE and 2D/3D connectivity indices. 1. Pyrimidyl derivatives", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, vol. 42, no. 5, 2002, pages 1194 - 1203, XP002969550
Attorney, Agent or Firm:
Takashima, Hajime (2-14 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka, JP)
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