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Title:
C-TERMINAL MUTANT OF APOLIPOPROTEIN L-I AND ITS THERAPEUTICAL OR PROPHYLACTIC USE
Document Type and Number:
WIPO Patent Application WO/2011/020497
Kind Code:
A1
Abstract:
The present invention is in the field of Molecular Biology and is related to new c-terminal mutants of Apolipoprotein L-I and their pharmaceutical use especially for a treatment and/or a prevention of diseases induced in mammals especially in cattle by Trypanosoma, especially African Trypanosoma, more particularly Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma Evansi, Trypanosoma congolense and/or Trypanosoma vivax.

Inventors:
PAYS ETIENNE (BE)
LECORDIER LAURENCE (BE)
POELVOORDE PHILIPPE (BE)
Application Number:
PCT/EP2009/060687
Publication Date:
February 24, 2011
Filing Date:
August 18, 2009
Export Citation:
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Assignee:
UNIV BRUXELLES (BE)
PAYS ETIENNE (BE)
LECORDIER LAURENCE (BE)
POELVOORDE PHILIPPE (BE)
International Classes:
C12N15/12; A01K67/027; A61K38/17; C07K14/775
Domestic Patent References:
WO2004012757A22004-02-12
WO2007039645A12007-04-12
Foreign References:
Other References:
PAYS E ET AL: "Human innate immunity against African trypanosomes", CURRENT OPINION IN IMMUNOLOGY, ELSEVIER, OXFORD, GB LNKD- DOI:10.1016/J.COI.2009.05.024, vol. 21, no. 5, 24 June 2009 (2009-06-24), pages 493 - 498, XP026682559, ISSN: 0952-7915, [retrieved on 20090624]
PEREZ-MORGA DAVID ET AL: "Apolipoprotein L-1 promotes trypanosome lysis by forming pores in lysosomal membranes", SCIENCE (WASHINGTON D C), vol. 309, no. 5733, July 2005 (2005-07-01), pages 469 - 472,464, XP002584508, ISSN: 0036-8075
VANHAMME LUC ET AL: "Apolipoprotein L-I is the trypanosome lytic factor of human serum.", NATURE (LONDON), vol. 422, no. 6927, 6 March 2003 (2003-03-06), pages 83 - 87, XP002584509, ISSN: 0028-0836
MOLINA-PORTELA MARIA PILAR ET AL: "Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 205, no. 8, August 2008 (2008-08-01), pages 1721 - 1728, XP002584510, ISSN: 0022-1007
POELVOORDE PHILIPPE ET AL: "Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera.", MOLECULAR & BIOCHEMICAL PARASITOLOGY, vol. 134, no. 1, March 2004 (2004-03-01), pages 155 - 157, XP002584511, ISSN: 0166-6851
LECORDIER LAURENCE ET AL: "C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense", PLOS PATHOGENS, vol. 5, no. 12, E1000685, 4 December 2009 (2009-12-04), pages 1 - 11, XP002584512
Attorney, Agent or Firm:
PRONOVEM - OFFICE VAN MALDEREN (Brussels, BE)
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