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Title:
C-TYPE LECTIN BINDING MOLECULES, IDENTIFICATION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004041292
Kind Code:
A3
Abstract:
C-type lectins are involved in the binding of many different types of carbohydrates. Considering their diversity in kind and expression of different types of cells, the influence of such binding is very diverse and dependent among others on the type of cell, the environment of the cell and the type of carbohydrate bound. In the present invention new carbohydrate specificities of C-type lectins are disclosed. Interference with this binding property has uses in the prevention of pathogen binding and also in influencing signaling pathways in the C-type lectin containing cell, particularly in Toll like receptor expressing cells such as dendritic cells. Also provided is the use of the carbohydrate specificity to enhance antigen presentation by antigen presenting cells and to manipulate migration of C-type lectin containing cells and the interaction of C-type lectin expressing cells with cellular ligands on neighboring cells.

Inventors:
GEIJTENBEEK TEUNIS BERNARD HER (NL)
VAN KOOYK YVETTE (NL)
Application Number:
PCT/NL2003/000781
Publication Date:
July 29, 2004
Filing Date:
November 07, 2003
Export Citation:
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Assignee:
VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS (NL)
GEIJTENBEEK TEUNIS BERNARD HER (NL)
VAN KOOYK YVETTE (NL)
International Classes:
A61K31/7028; (IPC1-7): A61K31/7028
Foreign References:
Other References:
FEINBERG ET AL.: "STRUCTURAL BASIS FOR SELECTIVE RECOGNITION OF OLIGOSACCARIDES BY DC-SIGN AND DC-SIGNR", SCIENCE, vol. 294, 7 December 2001 (2001-12-07), pages 2163 - 2166, XP002239677
CLAUDIUS ET AL.: "KINETIC AND EQUILIBRIUM CHARACTERIZATION OF INTERACTIONS BETWEEN GLYCOPEPTIDE ANTIBIOTICS AND SODIUM CARBOXYETHYL STARCH", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 144, 1996, pages 71 - 79, XP002239678
SCHOFIELD ET AL.: "SYNTHETIC GPI AS A CANDIDATE ANTI-TOXIC VACCINE IN A MODEL OF MALARIA", NATURE, vol. 418, 15 August 2002 (2002-08-15), pages 785 - 789, XP002239679
YAMAMOTO, KAZUO ET AL: "Interaction of Immobilized Recombinant Mouse C-Type Macrophage Lectin wit Glycopeptides and Oligosaccharides", BIOCHEMISTRY (1994), 33(26), 8159-66, 1994, XP002239680
MUTO ET AL.: "BIOLOGICAL ACTIVITIES OF HUMAN MANNOSE-BINDING LECTIN BOUND TO 2 DIFFERENT LIGAND SUGAR STRUCTURES, LEWIS A AND LEWIS B ANTIGENS AND HIGH-MANNOSE TYPE OLIGOSACCARIDES", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1527, 2001, pages 39 - 46, XP002239681
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