Title:
C12 MODIFIED ERYTHROMYCIN MACROLIDES AND KETOLIDES HAVING ANTIBACTERIAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO2003004509
Kind Code:
A3
Abstract:
Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
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Inventors:
CHU DANIEL (US)
BURGER MATTHEW (US)
LIN XIAODONG (US)
CARROLL GEORGIA LAW (US)
PLATTNER JACOB (US)
RICO ALICE (US)
BURGER MATTHEW (US)
LIN XIAODONG (US)
CARROLL GEORGIA LAW (US)
PLATTNER JACOB (US)
RICO ALICE (US)
Application Number:
PCT/US2002/021209
Publication Date:
May 15, 2003
Filing Date:
July 03, 2002
Export Citation:
Assignee:
CHIRON CORP (US)
CHU DANIEL (US)
BURGER MATTHEW (US)
LIN XIAODONG (US)
CARROLL GEORGIA LAW (US)
PLATTNER JACOB (US)
RICO ALICE (US)
CHU DANIEL (US)
BURGER MATTHEW (US)
LIN XIAODONG (US)
CARROLL GEORGIA LAW (US)
PLATTNER JACOB (US)
RICO ALICE (US)
International Classes:
A01N43/22; A01N43/32; A01N43/50; A01N43/90; A61K31/7048; A61K31/7052; A61P31/04; A61P43/00; C07H17/08; (IPC1-7): C07H17/08; A61K31/7048; A61P31/04
Domestic Patent References:
| WO1999035157A1 | 1999-07-15 | |||
| WO1998042720A1 | 1998-10-01 |
Foreign References:
| EP0303471A2 | 1989-02-15 | |||
| US6063561A | 2000-05-16 | |||
| US5866549A | 1999-02-02 | |||
| US5656607A | 1997-08-12 | |||
| EP0945459A1 | 1999-09-29 | |||
| US6075011A | 2000-06-13 | |||
| US5750510A | 1998-05-12 |
Other References:
J.R. JACOBSEN ET AL.: "Precursor-directed biosynthesis of 12-ethyl erythromycin", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, 1998, pages 1171 - 1177, XP002217168
P.A. LARTY ET AL.: "Synthesis and activity of C-21 alkylamino derivatives of (9R)-erythromycylamine", THE JOURNAL OF ANTIBIOTICS, vol. 45, 1992, pages 380 - 385, XP002217169
J.R. HAUSKE ET AL.: "Aglycon modifications of Erythromycin A: Regiospecific and stereospecific elaboration of the C-12 position", J. ORG. CHEM., vol. 52, 1987, pages 4622 - 4625, XP002233583
P.A. LARTY ET AL.: "Synthesis and activity of C-21 alkylamino derivatives of (9R)-erythromycylamine", THE JOURNAL OF ANTIBIOTICS, vol. 45, 1992, pages 380 - 385, XP002217169
J.R. HAUSKE ET AL.: "Aglycon modifications of Erythromycin A: Regiospecific and stereospecific elaboration of the C-12 position", J. ORG. CHEM., vol. 52, 1987, pages 4622 - 4625, XP002233583
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