Title:
CANCER METASTASIS INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2020/130120
Kind Code:
A1
Abstract:
The present invention pertains to a novel cancer metastasis inhibitor. According to the present invention, a cancer metastasis inhibitor, which is characterized by comprising as an active ingredient a compound represented by formula (I) [wherein each symbol is as defined in the description] or a pharmaceutically acceptable salt thereof, can be provided.
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Inventors:
ASHIHARA EISHI (JP)
NAKAMURA SEIKOU (JP)
YAMASHITA MASAYUKI (JP)
NAKAMURA SEIKOU (JP)
YAMASHITA MASAYUKI (JP)
Application Number:
PCT/JP2019/049993
Publication Date:
June 25, 2020
Filing Date:
December 20, 2019
Export Citation:
Assignee:
KYOTO PHARMACEUTICAL UNIV (JP)
International Classes:
A61K31/37; A61K45/00; A61P35/04; A61P43/00; C07D311/12; C07D311/14
Domestic Patent References:
| WO1994024119A1 | 1994-10-27 |
Foreign References:
| JPS564604A | 1981-01-19 | |||
| JPS4736384B1 | 1972-09-12 | |||
| JPS63145304A | 1988-06-17 | |||
| JPH0229651A | 1990-01-31 | |||
| JP2006512328A | 2006-04-13 | |||
| CN106008434A | 2016-10-12 | |||
| CN103275043A | 2013-09-04 | |||
| JP2017534627A | 2017-11-24 |
Other References:
MLADENOVIC, M. ET AL.: "Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-0ne Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure-Activity Relationships Predictive Models", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 57, no. 4, 2017, pages 787 - 814, XP055721724
HU , Y. ET AL.: "Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, no. 1, 26 October 2018 (2018-10-26), pages 15 - 30, XP055721725
RAUHAMAKI, S. ET AL.: "Structure-activity relationship analysis of 3- phenylcoumarin-based monoamine oxidase B inhibitors", FRONTIERS IN CHEMISTRY, vol. 6, 2 March 2018 (2018-03-02), XP055721726
SUGIYAMA, YUKI ET AL.: "Non-official translation: Coumarin-based compounds inhibit migration and invasion of murine osteosarcoma LM-8 cells", PROGRAM PROCEEDINGS OF THE 28TH MEETING OF THE JAPANESE ASSOCIATION FOR METASTASIS RESEARCH, 2 August 2019 (2019-08-02)
HU , Y. ET AL.: "Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 34, no. 1, 26 October 2018 (2018-10-26), pages 15 - 30, XP055721725
RAUHAMAKI, S. ET AL.: "Structure-activity relationship analysis of 3- phenylcoumarin-based monoamine oxidase B inhibitors", FRONTIERS IN CHEMISTRY, vol. 6, 2 March 2018 (2018-03-02), XP055721726
SUGIYAMA, YUKI ET AL.: "Non-official translation: Coumarin-based compounds inhibit migration and invasion of murine osteosarcoma LM-8 cells", PROGRAM PROCEEDINGS OF THE 28TH MEETING OF THE JAPANESE ASSOCIATION FOR METASTASIS RESEARCH, 2 August 2019 (2019-08-02)
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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