CARBOXY SUBSTITUTED (HETERO) AROMATIC RING DERIVATIVES AND PREPARATION METHOD AND USES THEREOF

Title:

CARBOXY SUBSTITUTED (HETERO) AROMATIC RING DERIVATIVES AND PREPARATION METHOD AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/036404

Kind Code:

A1

Abstract:

Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine oxidase and urate anion transporter 1, and also can be used in the treatment or prevention of diseases associated with high blood uric acid level in mammals, especially humans.

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Inventors:

YANG XINYE (CN)
HUANG CHANGWEI (CN)
MA FACHENG (CN)
ZHANG JI (CN)
WANG XIAOJUN (CN)
ZHANG YINGJUN (CN)

Application Number:

PCT/CN2016/097660

Publication Date:

March 09, 2017

Filing Date:

August 31, 2016

Export Citation:

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Assignee:

SUNSHINE LAKE PHARMA CO LTD (CN)

International Classes:

C07D215/02; A61K31/33; A61K31/404; A61P3/10; C07D209/04; C07D235/08; C07D237/28; C07D249/18; C07D261/20; C07D263/54; C07D291/08

Domestic Patent References:

WO2010093191A2	2010-08-19
WO2011043568A2	2011-04-14

Foreign References:

US5614520A	1997-03-25
JP2015214527A	2015-12-03
US20110201815A1	2011-08-18
US20130217878A1	2013-08-22

Other References:

ENOMOTO, KIMURA HCHAIROUNGDUA A ET AL.: "Molecular identification of a renal urate anion exchanger that regulates blood urate levels [J", NATURE, vol. 417, no. 6887, 2002, pages 447 - 452, XP002314925
S TAKAHASHI, ANN. RHEUM. DIS., vol. 62, 2003, pages 572 - 575
See also references of EP 3344604A4

Attorney, Agent or Firm:

TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)

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