Title:
CARBOXYLIC ACID AMIDES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THE USE AND PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO2001007020
Kind Code:
A3
Abstract:
The invention relates to the use of carboxylic acid amides of general formula (I) for inhibiting telomerase, wherein A, B and R1 to R5 are defined as per claim (1). The invention also relates to novel carboxylic acid amides of general formula (I) according to claim (2), to methods for the production thereof, to medicaments containing these compounds and to the use and production thereof. The compounds of formula (I) are analogous agents and derivatives in the broader sense of N-phenyl cinnamic acid amides. Diseases, which can be treated, with said compounds include tumorous diseases, epidermal hyperproliferation, inflammatory processes (rheumatoid arthritis), diseases of the immune system and parasitic diseases, (helminithic diseases, fungal diseases), infections by protozoic pathogens).
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Inventors:
HAUEL NORBERT
PRIEPKE HENNING
DAMM KLAUS
SCHNAPP ANDREAS
PRIEPKE HENNING
DAMM KLAUS
SCHNAPP ANDREAS
Application Number:
PCT/EP2000/007057
Publication Date:
September 19, 2002
Filing Date:
July 22, 2000
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
International Classes:
A61K31/16; C07D295/10; A61K31/165; A61K31/167; A61K31/192; A61K31/194; A61K31/36; A61K31/381; A61K31/41; A61K31/415; A61K31/4164; A61K31/4184; A61K31/439; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/4465; A61K31/47; A61K31/495; A61K31/5375; A61P35/00; A61P43/00; C07C233/46; C07C233/52; C07C233/55; C07C233/63; C07C233/81; C07C235/38; C07C237/30; C07C237/42; C07C237/52; C07C239/20; C07C243/38; C07C255/24; C07C271/20; C07C271/28; C07C275/42; C07C309/51; C07C309/66; C07C311/08; C07C311/13; C07C311/21; C07C311/39; C07C311/46; C07C311/51; C07D207/20; C07D211/16; C07D211/26; C07D213/40; C07D213/53; C07D213/56; C07D213/75; C07D213/79; C07D215/48; C07D215/56; C07D231/12; C07D231/14; C07D231/38; C07D233/26; C07D233/61; C07D233/88; C07D233/90; C07D235/06; C07D235/08; C07D257/04; C07D295/12; C07D295/155; C07D295/192; C07D295/22; C07D307/79; C07D311/06; C07D311/12; C07D317/50; C07D317/68; C07D333/36; C07D333/38; C07D333/40; C07D333/58; C07D333/60; C07D405/04; C07D487/04; (IPC1-7): A61K31/00
Domestic Patent References:
WO1999007669A1 | 1999-02-18 |
Foreign References:
EP0511477A1 | 1992-11-04 | |||
US3940422A | 1976-02-24 |
Other References:
DATABASE WPI Section Ch Week 199416, Derwent World Patents Index; Class B05, AN 1994-128759, XP002186009
DATABASE WPI Section Ch Week 198537, Derwent World Patents Index; Class B05, AN 1985-226638, XP002186010
DATABASE WPI Section Ch Week 198528, Derwent World Patents Index; Class B03, AN 1985-168505, XP002186011
YASHIRO, M., ET AL.: "Tranilast (N-(3,4-dimethoxycinnamoyl)anthranilic acid) down-regulates the growth of scirrhous gastric cancer", ANTICANCER RES., vol. 17, no. 2A, 1997, pages 895 - 900, XP001034866
RALPH, R. K. ET AL: "Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells", CANCER LETT. (SHANNON, IREL.) (1990), 49(3), 181-5, 1990, XP001050403
NAKAI H ET AL: "NEW POTENT ANTAGONISTS OF LEUKOTRIENES C4 AND D4 1. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 31, no. 1, 1988, pages 84 - 91, XP000608223, ISSN: 0022-2623
NIE, L. ET AL.: "Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca2+-permeable channel", CELL CALCIUM, vol. 22, no. 2, 1997, pages 75 - 82, XP001050575
LIU, Y., ET AL: "Synthesis and antiinflammatory activity of (E)-4-cinnamoyloxystyrene derivatives", ZHONGGUO YAOWU HUAXUE ZAZHI (CHINESE JOURNAL OF MEDICINAL CHEMISTRY), vol. 9, no. 3, 1999, pages 186 - 191, XP001051016
NISHIZAWA, Y., ET AL.: "Effects of antiallergic drugs on the proliferation of estrogen-sensitive mouse Leydig cell line", ANTICANCER RES., vol. 19, no. 3A, 1996, pages 1241 - 1245, XP001050577
MURAHASHI K ET AL: "The combination therapy of scirrhous gastric carcinoma with tranilast and cisplatin.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 39, March 1998 (1998-03-01), 89th Annual Meeting of the American Association for Cancer Research;New Orleans, Louisiana, USA; March 28-April 1, 1998, March, 1998, pages 308, XP001050586, ISSN: 0197-016X
BECKMAN J. K., ET AL.: "Phospholipid peroxidation in tumor promoter-exposed mouse skin.", CARCINOGENESIS, vol. 15, no. 12, 1994, pages 2937 - 2944, XP002186008
MURAHASHI K ET AL: "Tranilast, a fibroblasts inhibitor, inhibits the metatasis of gastric cancer cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 40, March 1999 (1999-03-01), 90th Annual Meeting of the American Association for Cancer Research;Philadelphia, Pennsylvania, USA; April 10-14, 1999, March, 1999, pages 704, XP001050587, ISSN: 0197-016X
ISAJI M ET AL: "TRANILAST INHIBITS THE PROLIFERATION, CHEMOTAXIS AND TUBE FORMATIONOF HUMAN MICROVASCULAR ENDOTHELIAL CELLS IN VITRO AND ANGIOGENESIS IN VIVO", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 122, no. 6, November 1997 (1997-11-01), pages 1061 - 1066, XP000997892, ISSN: 0007-1188
KUMAZAWA, T., ET AL.: "(E)-4-{2-[[3-(Indol-5-yl)-1-oxo-2-butenyl]amino]phenoxy}butyric Acid Derivatives: A New Class of Steroid 5.alpha.-Reductase Inhibitors in the Rat Prostate. 1", J. MED. CHEM., vol. 38, no. 15, 1995, pages 2887 - 2892, XP001041884
DATABASE WPI Section Ch Week 198537, Derwent World Patents Index; Class B05, AN 1985-226638, XP002186010
DATABASE WPI Section Ch Week 198528, Derwent World Patents Index; Class B03, AN 1985-168505, XP002186011
YASHIRO, M., ET AL.: "Tranilast (N-(3,4-dimethoxycinnamoyl)anthranilic acid) down-regulates the growth of scirrhous gastric cancer", ANTICANCER RES., vol. 17, no. 2A, 1997, pages 895 - 900, XP001034866
RALPH, R. K. ET AL: "Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells", CANCER LETT. (SHANNON, IREL.) (1990), 49(3), 181-5, 1990, XP001050403
NAKAI H ET AL: "NEW POTENT ANTAGONISTS OF LEUKOTRIENES C4 AND D4 1. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 31, no. 1, 1988, pages 84 - 91, XP000608223, ISSN: 0022-2623
NIE, L. ET AL.: "Inhibition of proliferation of MCF-7 breast cancer cells by a blocker of Ca2+-permeable channel", CELL CALCIUM, vol. 22, no. 2, 1997, pages 75 - 82, XP001050575
LIU, Y., ET AL: "Synthesis and antiinflammatory activity of (E)-4-cinnamoyloxystyrene derivatives", ZHONGGUO YAOWU HUAXUE ZAZHI (CHINESE JOURNAL OF MEDICINAL CHEMISTRY), vol. 9, no. 3, 1999, pages 186 - 191, XP001051016
NISHIZAWA, Y., ET AL.: "Effects of antiallergic drugs on the proliferation of estrogen-sensitive mouse Leydig cell line", ANTICANCER RES., vol. 19, no. 3A, 1996, pages 1241 - 1245, XP001050577
MURAHASHI K ET AL: "The combination therapy of scirrhous gastric carcinoma with tranilast and cisplatin.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 39, March 1998 (1998-03-01), 89th Annual Meeting of the American Association for Cancer Research;New Orleans, Louisiana, USA; March 28-April 1, 1998, March, 1998, pages 308, XP001050586, ISSN: 0197-016X
BECKMAN J. K., ET AL.: "Phospholipid peroxidation in tumor promoter-exposed mouse skin.", CARCINOGENESIS, vol. 15, no. 12, 1994, pages 2937 - 2944, XP002186008
MURAHASHI K ET AL: "Tranilast, a fibroblasts inhibitor, inhibits the metatasis of gastric cancer cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 40, March 1999 (1999-03-01), 90th Annual Meeting of the American Association for Cancer Research;Philadelphia, Pennsylvania, USA; April 10-14, 1999, March, 1999, pages 704, XP001050587, ISSN: 0197-016X
ISAJI M ET AL: "TRANILAST INHIBITS THE PROLIFERATION, CHEMOTAXIS AND TUBE FORMATIONOF HUMAN MICROVASCULAR ENDOTHELIAL CELLS IN VITRO AND ANGIOGENESIS IN VIVO", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 122, no. 6, November 1997 (1997-11-01), pages 1061 - 1066, XP000997892, ISSN: 0007-1188
KUMAZAWA, T., ET AL.: "(E)-4-{2-[[3-(Indol-5-yl)-1-oxo-2-butenyl]amino]phenoxy}butyric Acid Derivatives: A New Class of Steroid 5.alpha.-Reductase Inhibitors in the Rat Prostate. 1", J. MED. CHEM., vol. 38, no. 15, 1995, pages 2887 - 2892, XP001041884
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