Title:
CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES
Document Type and Number:
WIPO Patent Application WO/2013/090454
Kind Code:
A3
Abstract:
The invention relates to compounds that are characterized by possessing at least four cycles (A-C and phenylene ring). Such compounds modulate the glucagon-like peptide 1 (GLP-1) receptor and have a therapeutic use that includes diseases such as diabetes, obesity and excessive appetite. The compounds act as modulators or potentiators of the GLP-1 receptor, or act with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide. Claimed are compounds of the fol lowing genera structure (" ﹋ "1 represents undefined stereochemistry) : [Formula I] where the variables A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined in the claims.
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Inventors:
BOEHM MARCUS F (US)
MARTINBOROUGH ESTHER (US)
MOORJANI MANISHA (US)
TAMIYA JUNKO (US)
HUANG LIMING (US)
YEAGER ADAM R (US)
BRAHMACHARY ENUGURTHI (US)
FOWLER THOMAS (GB)
NOVAK ANDREW (GB)
MEGHANI PREMJI (GB)
KNAGGS MICHAEL (GB)
MARTINBOROUGH ESTHER (US)
MOORJANI MANISHA (US)
TAMIYA JUNKO (US)
HUANG LIMING (US)
YEAGER ADAM R (US)
BRAHMACHARY ENUGURTHI (US)
FOWLER THOMAS (GB)
NOVAK ANDREW (GB)
MEGHANI PREMJI (GB)
KNAGGS MICHAEL (GB)
Application Number:
PCT/US2012/069289
Publication Date:
October 10, 2013
Filing Date:
December 12, 2012
Export Citation:
Assignee:
RECEPTOS INC (US)
International Classes:
C07D211/22; A61K31/4245; A61K31/433; A61K31/454; A61K31/4545; A61K31/4709; A61K31/505; A61K31/506; A61K31/551; A61K38/26; A61P3/10; C07D233/54; C07D233/60; C07D239/26; C07D239/34; C07D241/08; C07D243/08; C07D255/02; C07D263/32; C07D271/06; C07D271/107; C07D277/24; C07D285/12; C07D401/04; C07D403/04; C07D403/12; C07D409/12; C07D413/04; C07D413/10; C07D413/12; C07D413/14; C07D417/12; C07D495/04
Domestic Patent References:
| WO2011094890A1 | 2011-08-11 | |||
| WO1999010312A1 | 1999-03-04 | |||
| WO2005077915A1 | 2005-08-25 | |||
| WO2011097300A1 | 2011-08-11 |
Foreign References:
| EP1477482A1 | 2004-11-17 | |||
| EP1700850A1 | 2006-09-13 | |||
| US20050222141A1 | 2005-10-06 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; THORSETT, EUGENE D. ET AL: "Preparation of N-sulfonylated dipeptide derivatives as inhibitors of leukocyte adhesion mediated by VLA-4", XP002703734, retrieved from STN Database accession no. 2003:485719
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; THORSETT, EUGENE D. ET AL: "Preparation of N-sulfonylproline dipeptide derivatives and analogs as inhibitors of leukocyte adhesion mediated by VLA-4", XP002703735, retrieved from STN Database accession no. 1999:113712
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; THORSETT, EUGENE D. ET AL: "Preparation of N-sulfonylproline dipeptide derivatives and analogs as inhibitors of leukocyte adhesion mediated by VLA-4", XP002703735, retrieved from STN Database accession no. 1999:113712
Attorney, Agent or Firm:
HERMANNS, Karl, R. et al. (Suite 5400701 Fifth Avenu, Seattle Washington, US)
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