CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS

WIPO Patent Application WO2000067746

A8

A method for the inhibition of the binding of alpha 4 beta 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which alpha 4 beta 1 is involved.

BIEDIGER RONALD J (US)
CHEN QI (US)
HOLLAND GEORGE W (US)
KASSIR JAMAL M (US)
LI WEN (US)
MARKET ROBERT V (US)
SCOTT IAN L (US)
WU CHENGDE (US)

PCT/US2000/012303

February 28, 2002

May 05, 2000

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TEXAS BIOTECHNOLOGY CORP (US)
BIEDIGER RONALD J (US)
CHEN QI (US)
HOLLAND GEORGE W (US)
KASSIR JAMAL M (US)
LI WEN (US)
MARKET ROBERT V (US)
SCOTT IAN L (US)
WU CHENGDE (US)

C07D239/36; A61K31/215; A61K31/216; A61K31/335; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/4015; A61K31/4025; A61K31/44; A61K31/4409; A61K31/4412; A61K31/4427; A61K31/445; A61K31/4523; A61K31/47; A61K31/506; A61K31/55; A61P1/00; A61P3/10; A61P9/10; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07C69/66; C07C275/32; C07C275/34; C07D207/04; C07D207/18; C07D207/416; C07D211/68; C07D211/72; C07D213/02; C07D213/64; C07D213/69; C07D213/73; C07D213/74; C07D213/75; C07D215/00; C07D215/38; C07D221/04; C07D233/96; C07D239/46; C07D239/47; C07D317/58; C07D333/20; C07D401/06; C07D405/12; C07D409/12; C07D409/14; C07D471/04; C07D487/04; (IPC1-7): A61K31/215; A61K31/335; A61K31/38; A61K31/4025; A61K31/44; A61K31/4427; A61K31/445; A61K31/4523; A61K31/47; A61K31/506; C07C69/66; C07D207/04; C07D207/18; C07D211/68; C07D211/72; C07D213/02; C07D215/00

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