Title:
CARBOXYLIC ACID-INTRODUCED PSMA-TARGETING COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/139012
Kind Code:
A1
Abstract:
The present invention relates to a 18F-labeled compound for diagnosing prostate cancer and a use thereof. The carboxylic acid-introduced compound of the present invention forms strong ion-pair bonds (salt-bridge interactions) with arginine residues present at PSMA protein-binding sites, and thus has high binding affinity, and has rapid background radiation removal effects in vivo due to the hydrophilic properties of carboxylic acid, and less non-specific binding.
Inventors:
CHI DAE YOON (KR)
LEE BYOUNG SE (KR)
CHU SO YOUNG (KR)
JEONG HYEON JIN (KR)
KIM MIN HWAN (KR)
LEE KYO CHUL (KR)
LEE YONG JIN (KR)
PARK JI AE (KR)
KANG CHOONG MO (KR)
LIM SANG MOO (KR)
LEE BYOUNG SE (KR)
CHU SO YOUNG (KR)
JEONG HYEON JIN (KR)
KIM MIN HWAN (KR)
LEE KYO CHUL (KR)
LEE YONG JIN (KR)
PARK JI AE (KR)
KANG CHOONG MO (KR)
LIM SANG MOO (KR)
Application Number:
PCT/KR2019/018594
Publication Date:
July 02, 2020
Filing Date:
December 27, 2019
Export Citation:
Assignee:
FUTURECHEM CO LTD (KR)
International Classes:
C07D249/04; A61K31/4192; A61P35/00; C07C275/12; C07D213/56; G01N33/574
Domestic Patent References:
| WO2017223357A1 | 2017-12-28 | |||
| WO2017027870A1 | 2017-02-16 | |||
| WO2008058192A2 | 2008-05-15 | |||
| WO2018005625A1 | 2018-01-04 |
Foreign References:
| KR20180134918A | 2018-12-19 |
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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