Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
CARBOXYPEPTIDASES B FROM ANOPHELES GAMBIAE. COMPOSITIONS COMPRISING THEM, VACCINE APPLICATIONS AND USE AS THERAPEUTICAL TARGETS
Document Type and Number:
WIPO Patent Application WO2005103243
Kind Code:
A3
Abstract:
The present invention provides two carboxypeptidase B enzymes from Anopheles gambiae and homologs thereof. The present invention also provides compositions and vaccines containing the carboxypeptidase B enzymes, as well as antibodies directed thereto and various methods of using the same. The methods of the present invention include a method of blocking Plasmodium development and a method of identifying compounds that inhibit carboxypeptidase B activity.

Inventors:
LAVAZEC CATHERINE (FR)
BOURGOUIN CATHERINE (FR)
BOUDIN CHRISTIAN (FR)
BONNET SARAH (FR)
Application Number:
PCT/EP2005/005233
Publication Date:
June 01, 2006
Filing Date:
April 20, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
PASTEUR INSTITUT (FR)
CENTRE NAT RECH SCIENT (FR)
INST RECH DEVELOPPEMENT IRD (FR)
LAVAZEC CATHERINE (FR)
BOURGOUIN CATHERINE (FR)
BOUDIN CHRISTIAN (FR)
BONNET SARAH (FR)
International Classes:
A61K39/00; A61K39/015; C07H21/04; C07K16/20; C07K16/40; C12N9/48; C12N9/72; C12Q1/68
Foreign References:
US5474901A1995-12-12
Other References:
LAVAZEC C ET AL: "cpbAg1 encodes an active carboxypeptidase B expressed in the midgut of Anopheles gambiae", INSECT MOLECULAR BIOLOGY, vol. 14, no. 2, April 2005 (2005-04-01), pages 163 - 174, XP002341172, ISSN: 0962-1075
SHAHABUDDIN MOHAMMED ET AL: "Antibody-mediated inhibition of Aedes aegypti midgut trypsins blocks sporogonic development of Plasmodium gallinaceum", INFECTION AND IMMUNITY, vol. 64, no. 3, 1996, pages 739 - 743, XP002341173, ISSN: 0019-9567
MOSKALYK L A: "Carboxypeptidase B in Anopheles gambiae (Diptera: Culicidae): Effects of abdominal distention and blood ingestion", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 35, no. 3, May 1998 (1998-05-01), pages 216 - 221, XP008051141, ISSN: 0022-2585
DATABASE UniProt [online] 1 March 2004 (2004-03-01), "ENSANGP00000020640 (Fragment).", XP002341180, retrieved from EBI accession no. UNIPROT:Q7Q5T8 Database accession no. Q7Q5T8
LAL ALTAF A ET AL: "Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 98, no. 9, 24 April 2001 (2001-04-24), pages 5228 - 5233, XP002341174, ISSN: 0027-8424
DINGLASAN RHOEL R ET AL: "Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi.", INFECTION AND IMMUNITY, vol. 71, no. 12, December 2003 (2003-12-01), pages 6995 - 7001, XP002341175, ISSN: 0019-9567
NORIEGA F G ET AL: "Midgut exopeptidase activities in Aedes aegypti are induced by blood feeding", JOURNAL OF INSECT PHYSIOLOGY, vol. 48, no. 2, February 2002 (2002-02-01), pages 205 - 212, XP002341176, ISSN: 0022-1910
EDWARDS MARTEN J ET AL: "Rapid induction by a blood meal of a carboxypeptidase gene in the gut of the mosquito Anopheles gambiae", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 27, no. 12, December 1997 (1997-12-01), pages 1063 - 1072, XP002341177, ISSN: 0965-1748
Download PDF: