Title:
CAROTENOID SYNTHASE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/199043
Kind Code:
A1
Abstract:
Provided are a novel carotenoid synthase with which it is possible to improve the productivity of carotenoids, and the use thereof. The protein of the present invention includes a phytoene desaturase domain, a phytoene synthase domain, and a lycopene cyclase domain.
Inventors:
AKI TSUNEHIRO (JP)
IWASAKA HIROAKI (JP)
SATOH NORIYUKI (JP)
KOYANAGI RYO (JP)
IWASAKA HIROAKI (JP)
SATOH NORIYUKI (JP)
KOYANAGI RYO (JP)
Application Number:
PCT/JP2015/067927
Publication Date:
December 30, 2015
Filing Date:
June 22, 2015
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
OKINAWA INST OF SCIENCE AND TECHNOLOGY SCHOOL CORP (JP)
OKINAWA INST OF SCIENCE AND TECHNOLOGY SCHOOL CORP (JP)
International Classes:
C12N15/09; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/00; C12N9/02; C12P23/00
Foreign References:
| JP2005532047A | 2005-10-27 | |||
| JP2006075097A | 2006-03-23 | |||
| JP2007516697A | 2007-06-28 |
Other References:
YOKOYAMA R ET AL.: "Taxonomic rearrangement of the genus Schizochytrium sensu lato based on morphology, chemotaxonomic characteristics, and 18S rRNA gene phylogeny (Thraustochytriaceae, Labyrinthulomycetes): emendation for Schizochytrium and erection of Aurantiochytrium and Oblongichytrium gen. nov.", MYCOSCIENCE, vol. 48, no. 4, 2007, pages 199 - 211, XP019521654
IWASAKA H ET AL.: "Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium", J. OLEO SCI., vol. 62, no. 9, 2013, pages 729 - 736, XP055247270
YAMASAKI T ET AL.: "Utilization of Shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid", J. BIOSCI. BIOENG., vol. 102, no. 4, 2006, pages 323 - 327, XP028042220
YAMASAKI T ET AL.: "Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls", J. BIOSCI. BIOENG., vol. 104, no. 3, 2007, pages 200 - 206, XP022314947
AKI T ET AL.: "Thraustochytrid as a potential source of carotenoids", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 80, no. 8, 2003, pages 789 - 794, XP055067749
ALVAREZ V ET AL.: "The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of p-carotene into astaxanthin and other xanthophylls", FUNGAL GENETICS AND BIOLOGY, vol. 43, no. 4, 2006, pages 216 - 272, XP024918914
ALCAINO J ET AL.: "Cloning of the cytochrome p450 reductase (crtR) gene and its involvement in the astaxanthin biosynthesis of Xanthophyllomyces dendrorhous", BMC MICROBIOLOGY, vol. 8, 2008, pages e169, XP055030548
MISAWA N ET AL.: "Metabolic engineering for the production of carotenoids in non- carotenogenic bacteria and yeasts", JOURNAL OF BIOTECHNOLOGY, vol. 59, 1998, pages 169 - 181, XP004113748
IWASAKA H ET AL.: "Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium", J. OLEO SCI., vol. 62, no. 9, 2013, pages 729 - 736, XP055247270
YAMASAKI T ET AL.: "Utilization of Shochu distillery wastewater for production of polyunsaturated fatty acids and xanthophylls using thraustochytrid", J. BIOSCI. BIOENG., vol. 102, no. 4, 2006, pages 323 - 327, XP028042220
YAMASAKI T ET AL.: "Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls", J. BIOSCI. BIOENG., vol. 104, no. 3, 2007, pages 200 - 206, XP022314947
AKI T ET AL.: "Thraustochytrid as a potential source of carotenoids", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 80, no. 8, 2003, pages 789 - 794, XP055067749
ALVAREZ V ET AL.: "The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of p-carotene into astaxanthin and other xanthophylls", FUNGAL GENETICS AND BIOLOGY, vol. 43, no. 4, 2006, pages 216 - 272, XP024918914
ALCAINO J ET AL.: "Cloning of the cytochrome p450 reductase (crtR) gene and its involvement in the astaxanthin biosynthesis of Xanthophyllomyces dendrorhous", BMC MICROBIOLOGY, vol. 8, 2008, pages e169, XP055030548
MISAWA N ET AL.: "Metabolic engineering for the production of carotenoids in non- carotenogenic bacteria and yeasts", JOURNAL OF BIOTECHNOLOGY, vol. 59, 1998, pages 169 - 181, XP004113748
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation HARAKENZO WORLD PATENT & TRADEMARK (JP)
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