Title:
CDK INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/166793
Kind Code:
A1
Abstract:
A compound serving as a selective CDK inhibitor, a pharmaceutical composition containing same, a useful intermediate for preparing the compound, and a use of the compound for preparing a drug for the treatment of cell proliferative diseases, such as cancer. The compound has the structure shown in formula (I-A).
Inventors:
YAN XIAOXIA (CN)
SUN DAQING (CN)
SUN DAQING (CN)
Application Number:
PCT/CN2022/074491
Publication Date:
August 11, 2022
Filing Date:
January 28, 2022
Export Citation:
Assignee:
SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61P35/00; C07D403/12
Domestic Patent References:
| WO2020180959A1 | 2020-09-10 | |||
| WO2021170076A1 | 2021-09-02 |
Foreign References:
| CN101490041A | 2009-07-22 | |||
| CN101511824A | 2009-08-19 | |||
| CN101044121A | 2007-09-26 | |||
| US20040162303A1 | 2004-08-19 | |||
| US20060014708A1 | 2006-01-19 | |||
| US20210047294A1 | 2021-02-18 | |||
| CN202110161786A | 2021-02-05 | |||
| CN202110483256A | 2021-04-30 | |||
| CN202111062178A | 2021-09-10 | |||
| CN202111398260A | 2021-11-19 | |||
| CN202210048365A | 2022-01-17 |
Other References:
DATABASE REGISTRY 27 August 2020 (2020-08-27), ANONYMOUS: "INDEX NAME NOT YET ASSIGNED", XP055956956, retrieved from STN Database accession no. 2463538-93-2
DATABASE REGISTRY 10 November 2021 (2021-11-10), ANONYMOUS: "2,4-Pyrimidinediamine, 5-chloro-N4-methyl-N2-[1-(methylsulfonyl)-4- piperidinyl]- (CA INDEX NAME)", XP055956965, retrieved from STN Database accession no. 2728273-28-5
HARPER, J. W.ADAMS, P. D.: "Cyclin-Dependent Kinases", CHEM. REV., vol. 101, 2001, pages 2511 - 2526
TADESSE SANSHABO ATPORTMAN NLIM ETILLEY WCALDON CEWANG S: "Targeting CDK2 in cancer: challenges and opportunities for therapy", DRUG DISCOVERY TODAY, vol. 25, 2020, pages 406 - 413, XP086060434, DOI: 10.1016/j.drudis.2019.12.001
DATABASE REGISTRY 10 November 2021 (2021-11-10), ANONYMOUS: "2,4-Pyrimidinediamine, 5-chloro-N4-methyl-N2-[1-(methylsulfonyl)-4- piperidinyl]- (CA INDEX NAME)", XP055956965, retrieved from STN Database accession no. 2728273-28-5
HARPER, J. W.ADAMS, P. D.: "Cyclin-Dependent Kinases", CHEM. REV., vol. 101, 2001, pages 2511 - 2526
TADESSE SANSHABO ATPORTMAN NLIM ETILLEY WCALDON CEWANG S: "Targeting CDK2 in cancer: challenges and opportunities for therapy", DRUG DISCOVERY TODAY, vol. 25, 2020, pages 406 - 413, XP086060434, DOI: 10.1016/j.drudis.2019.12.001
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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