Title:
CDK8 INHIBITOR AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2020/071550
Kind Code:
A1
Abstract:
The present invention provides a novel CDK8 inhibitor. The present invention relates to: a compound represented by general formula (I) (wherein the symbols are as defined in the description) or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition which contains this compound as an active ingredient. According to the present invention, this compound has CDK8 inhibitory activity; and the present invention is therefore able to provide a pharmaceutical product which is useful as a prophylactic and therapeutic agent for diseases related to CDK8, diseases related to bone metabolism such as osteoporosis and cell proliferative diseases such as cancers.
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Inventors:
SHIRAHASE HIROAKI (JP)
KITAO TATSUYA (JP)
TAKAHASHI KENJI (JP)
SHOJI YOSHIMICHI (JP)
TAKEDA SHIGEMITSU (JP)
KITAO TATSUYA (JP)
TAKAHASHI KENJI (JP)
SHOJI YOSHIMICHI (JP)
TAKEDA SHIGEMITSU (JP)
Application Number:
PCT/JP2019/039376
Publication Date:
April 09, 2020
Filing Date:
October 04, 2019
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
International Classes:
C07D209/12; A61K31/351; A61K31/37; A61K31/381; A61K31/397; A61K31/404; A61K31/4184; A61K31/437; A61K31/4375; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4704; A61K31/4709; A61K31/496; A61K31/498; A61K31/5377; A61K31/541; A61K31/675; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C07D215/48; C07D309/12; C07D311/14; C07D333/56; C07D401/04; C07D401/10; C07D401/14; C07D403/10; C07D403/14; C07D405/10; C07D405/12; C07D405/14; C07D407/10; C07D407/12; C07D409/12; C07D409/14; C07D471/04; C07F9/6574
Domestic Patent References:
| WO2010118009A1 | 2010-10-14 | |||
| WO2015082499A2 | 2015-06-11 | |||
| WO2013026942A1 | 2013-02-28 | |||
| WO2011136264A1 | 2011-11-03 | |||
| WO2018013430A2 | 2018-01-18 | |||
| WO2018136202A2 | 2018-07-26 | |||
| WO2019103050A1 | 2019-05-31 |
Foreign References:
| CN106316942A | 2017-01-11 | |||
| CN108191834A | 2018-06-22 | |||
| JP2008526824A | 2008-07-24 | |||
| JP2017522324A | 2017-08-10 |
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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