Title:
CELL VIABILITY DETECTION USING ELECTRICAL MEASUREMENTS
Document Type and Number:
WIPO Patent Application WO2003071140
Kind Code:
A3
Abstract:
A method of determining information about cell viability and other characteristics relating to cell membrane permeability is disclosed. The method involves determining the effect of a cell on current flow and relating that effect to a known standard which standard may be a known healthy cell and thereby deducing the viability of the cell being tested. The cells being tested can be subjected to different environmental conditions such as surrounding chemicals, temperature, pH and pressure to determine the effects of such conditions on cell viability and/or cell permeability. The cell being tested can be in a cell suspension, grown on s ubstarte, in tissue in vitro or in tissue in vivo. The method provides substantially instantaneous results and need not include the use of dyes or other markers.
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Inventors:
RUBINSKY BORIS (US)
HUANG YONG (US)
HUANG YONG (US)
Application Number:
PCT/US2003/005219
Publication Date:
June 10, 2004
Filing Date:
February 19, 2003
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
RUBINSKY BORIS (US)
HUANG YONG (US)
RUBINSKY BORIS (US)
HUANG YONG (US)
International Classes:
C12M1/34; G01N27/416; C12M3/00; C12N13/00; C12Q1/02; G01N27/02; G01N33/48; G01N33/487; G01N33/50; (IPC1-7): C12N13/00
Foreign References:
| US6482619B1 | 2002-11-19 | |||
| US5991697A | 1999-11-23 | |||
| US4810963A | 1989-03-07 | |||
| US6613211B1 | 2003-09-02 |
Other References:
See also references of EP 1483511A4
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