Title:
CERVICAL WAGAL STIMULATION INDUCED WEIGHT LOSS
Document Type and Number:
WIPO Patent Application WO2004064918
Kind Code:
B1
Abstract:
Apparatus and methods for treating obesity using chronic cervical vagal nerve stimulation (cVNS) of the left vagus trunk are disclosed. Four men and ten women, average age 46 years (SD ± 10) were treated with output current typically 0.75 mA, pulse frequency 30 Hz and width 250 or 500 µs, and duty cycle of 30 s power per five minutes. Mean intake weight was 91 kg (SD ±27, range 46 to 137 kg) with body mass index (BMI) 43 kg/m<2> (SD ±5, range 18 to 49 kg/mn<2>). After 6-12 months, obese patients had marked weight loss while normal weights were maintained. Decrease in BMI was consistently proportional to initial BMI. Average weight loss at one year was 7 kg (SD ± 3, range -6 to + 24) with mean drop in BMI of 2 kg/m<2> (SD ± 3, range -2 to +8)k. All patients denied any major dieting or exercise.
Inventors:
PARDO JOSE V
SHEIKH SOHAIL A
SHEIKH SOHAIL A
Application Number:
PCT/US2004/000889
Publication Date:
October 21, 2004
Filing Date:
January 14, 2004
Export Citation:
Assignee:
DEPT OF VETERANS AFFAIRS REHAB (US)
International Classes:
A61N1/36; (IPC1-7): A61N1/36; A61N1/05
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