Title:
CH1 DOMAIN VARIANTS ENGINEERED FOR PREFERENTIAL LIGHT CHAIN PAIRING AND MULTISPECIFIC ANTIBODIES COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2021/067404
Kind Code:
A3
Abstract:
CH1 domain variants engineered for preferential binding to either a kappa CL domain or a lambda CL domain, as well as polypeptides, e.g., antibody heavy chains or antibodies, comprising such engineered CH1 domain variants, and pharmaceutical compositions comprising such CH1 domain variants and/or such polypeptides, and methods for making and using such CH1 domain variants are provided. The CH1 domain variants minimize heavy chain-light chain mispairing and promote cognate heavy chain-light chain pairing, thereby improving the generation of multispecific, e.g., bispecific, antibodies. Also provided are methods of making CH1 domain variant libraries and methods of identifying one or more CH1 domain variants.
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Inventors:
SIVASUBRAMANIAN ARVIND (US)
SCHUTZ KEVIN (US)
HELBLE MICHAELA (US)
KRAULAND ERIC (US)
WIDBOOM PAUL (US)
SCHUTZ KEVIN (US)
HELBLE MICHAELA (US)
KRAULAND ERIC (US)
WIDBOOM PAUL (US)
Application Number:
PCT/US2020/053482
Publication Date:
May 14, 2021
Filing Date:
September 30, 2020
Export Citation:
Assignee:
ADIMAB LLC (US)
International Classes:
A61P43/00; C07K16/28; C07K16/00; C07K16/32
Foreign References:
| US20110064727A9 | 2011-03-17 | |||
| US20170081421A1 | 2017-03-23 |
Attorney, Agent or Firm:
TESKIN, Robin, L. et al. (US)
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