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Title:
CHEMICALLY ACTIVATED WATER-SOLUBLE PRODRUG
Document Type and Number:
WIPO Patent Application WO/2019/059344
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the formula, A represents A-0; X1 and X2 are the same as or different from each other and each independently represent a hydroxyl group or -O-C(=O)-Y-(C(R1A)(R1B))n-NH-R2, where X1 and X2 are not simultaneously hydroxyl groups, n is 2, 3, or 4, Y represents an oxygen atom or -NR4, R1A and R1B are the same as or different from each other and each independently represent a hydrogen atom, etc., and R2 represents a hydrogen atom, etc.; and Ra to Rd are optionally present, are the same as or different from each other, and each independently represent a hydrogen atom, etc.).

Inventors:
KAMIOKA SEIJI (JP)
SAWAYAMA YUSUKE (JP)
BAN HITOSHI (JP)
TAKANASHI YOSUKE (JP)
Application Number:
PCT/JP2018/035022
Publication Date:
March 28, 2019
Filing Date:
September 21, 2018
Export Citation:
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Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07C229/12; A61K31/265; A61K31/27; A61K31/352; A61K31/36; A61K31/381; A61K31/453; A61P43/00; C07C271/52; C07C271/54; C07D307/92; C07D311/92; C07D317/64; C07D405/04; C07D495/04
Domestic Patent References:
WO2016157052A12016-10-06
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Foreign References:
JP2010535238A2010-11-18
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Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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