Title:
CHEMICALLY PROGRAMMED VACCINATION
Document Type and Number:
WIPO Patent Application WO/2010/093706
Kind Code:
A3
Abstract:
Provided herein is a method for chemically programmed vaccination. Methods include inducing a covalent-binding polyclonal antibody response in a subject and programming the polyclonal response with a targeting compound.
Inventors:
BARBAS III CARLOS F (US)
Application Number:
PCT/US2010/023770
Publication Date:
November 10, 2011
Filing Date:
February 10, 2010
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
BARBAS III CARLOS F (US)
BARBAS III CARLOS F (US)
International Classes:
A61K31/216; A61K31/351; A61K31/397; A61K31/4192; A61K31/439; A61K31/496; A61K31/499; A61K39/00; C07C233/41; C07C279/16; C07D205/08; C07D309/28; C07D401/12; C07D405/12; C07D405/14; C07D451/04; C07D471/04; C07D471/10
Domestic Patent References:
| WO2003034995A2 | 2003-05-01 | |||
| WO2006094269A2 | 2006-09-08 | |||
| WO2009139863A2 | 2009-11-19 | |||
| WO2009148554A1 | 2009-12-10 | |||
| WO2004091542A2 | 2004-10-28 | |||
| WO2008006102A2 | 2008-01-10 |
Other References:
LI L-S ET AL: "Chemical Adaptor Immunotherapy: Design, Synthesis, and Evaluation of Novel Integrin-Targeting Devices", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM049666K, vol. 47, no. 23, 6 October 2004 (2004-10-06), pages 5630 - 5640, XP003006245, ISSN: 0022-2623
DOPPALAPUDI ET AL: "Chemically programmed antibodies: Endothelin receptor targeting CovX-Bodies(TM)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2006.10.009, vol. 17, no. 2, 11 January 2007 (2007-01-11), pages 501 - 506, XP005827262, ISSN: 0960-894X
RADER C ET AL: "A Humanized Aldolase Antibody for Selective Chemotherapy and Adaptor Immunotherapy", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB LNKD- DOI:10.1016/S0022-2836(03)00992-6, vol. 332, no. 4, 26 September 2003 (2003-09-26), pages 889 - 899, XP004454300, ISSN: 0022-2836
FANG GUO ET AL: "Breaking the one antibdy- on target axiom", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.0603822103, vol. 103, no. 29, 18 July 2006 (2006-07-18), pages 11009 - 11014, XP003024115, ISSN: 0027-8424
POPKOV MIKHAIL ET AL: "Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, UNITED STATES, SWITZERLAND, GERMANY LNKD- DOI:10.1002/IJC.21924, vol. 119, no. 5, 1 September 2006 (2006-09-01), pages 1194 - 1207, XP009121542, ISSN: 0020-7136, [retrieved on 20060328]
DOPPALAPUDI ET AL: "Chemically programmed antibodies: Endothelin receptor targeting CovX-Bodies(TM)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/J.BMCL.2006.10.009, vol. 17, no. 2, 11 January 2007 (2007-01-11), pages 501 - 506, XP005827262, ISSN: 0960-894X
RADER C ET AL: "A Humanized Aldolase Antibody for Selective Chemotherapy and Adaptor Immunotherapy", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB LNKD- DOI:10.1016/S0022-2836(03)00992-6, vol. 332, no. 4, 26 September 2003 (2003-09-26), pages 889 - 899, XP004454300, ISSN: 0022-2836
FANG GUO ET AL: "Breaking the one antibdy- on target axiom", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.0603822103, vol. 103, no. 29, 18 July 2006 (2006-07-18), pages 11009 - 11014, XP003024115, ISSN: 0027-8424
POPKOV MIKHAIL ET AL: "Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, UNITED STATES, SWITZERLAND, GERMANY LNKD- DOI:10.1002/IJC.21924, vol. 119, no. 5, 1 September 2006 (2006-09-01), pages 1194 - 1207, XP009121542, ISSN: 0020-7136, [retrieved on 20060328]
Attorney, Agent or Firm:
HAILE, Lisa, A. (4365 Executive Drive Suite 110, San Diego CA, US)
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