Title:
PT(Ⅳ) CHEMOTHERAPEUTIC PRODRUG AND CONTROLLED RELEASE THEREOF FOR TREATMENT OF TUMORS
Document Type and Number:
WIPO Patent Application WO/2022/111541
Kind Code:
A1
Abstract:
Provided is a Pt(IV) complex. As a prodrug, the Pt(IV) complex is activated by irradiation to release a Pt(II) complex for the treatment of tumors. Also provided is a pharmaceutical composition including the Pt(IV) complex, and the use of the Pt(IV) complex in the preparation of a drug for treating tumors by means of irradiation activation. Further provided is a kit including the Pt(IV) complex and the description, wherein the description indicates that radiotherapy is performed after administration to treat tumors.
Inventors:
LIU ZHIBO (CN)
FU QUNFENG (CN)
FU QUNFENG (CN)
Application Number:
PCT/CN2021/132886
Publication Date:
June 02, 2022
Filing Date:
November 24, 2021
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07F15/00; A61P35/00
Foreign References:
| CN106471006A | 2017-03-01 | |||
| CN108368143A | 2018-08-03 | |||
| CN106572991A | 2017-04-19 | |||
| CN202011337782A | 2020-11-25 |
Other References:
ZHANG MAOFAN; HAGAN C. TILDEN; MIN YUANGZENG; FOLEY HAYLEY; TIAN XI; YANG FEIFEI; MI YU; AU KIN MAN; MEDIK YUSRA; ROCHE KYLE; WAGN: "Nanoparticle co-delivery of wortmannin and cisplatin synergistically enhances chemoradiotherapy and reverses platinum resistance in ovarian cancer models", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 169, 31 March 2018 (2018-03-31), AMSTERDAM, NL , pages 1 - 10, XP085383527, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.03.055
HOU, XIAONAN: "Synthesis of Solid Supported Pt (Ⅳ) Complex and Oxidative Synthesis of Disulfide Bonds in Peptides", SCIENCE-ENGINEERING (I), CHINA DOCTORAL DISSERTATIONS& MASTER'S THESES FULL-TEXT DATABASE, 1 June 2017 (2017-06-01), pages 1 - 46, XP055932778, [retrieved on 20220617]
HOU, XIAONAN: "Synthesis of Solid Supported Pt (Ⅳ) Complex and Oxidative Synthesis of Disulfide Bonds in Peptides", SCIENCE-ENGINEERING (I), CHINA DOCTORAL DISSERTATIONS& MASTER'S THESES FULL-TEXT DATABASE, 1 June 2017 (2017-06-01), pages 1 - 46, XP055932778, [retrieved on 20220617]
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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