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Title:
CHIMERIC ANTIGEN RECEPTOR-ENGINEERED NK CELL, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/156786
Kind Code:
A1
Abstract:
Provided is a chimeric antigen receptor-engineered NK cell, the chimeric antigen receptor comprising: an extracellular target molecule binding domain, a transmembrane region domain, and an intracellular signal transduction domain. The transmembrane region domain connects the extracellular target molecule binding domain and the intracellular signal transduction domain, and fixes the two on the cell membrane of an NK cell. The intracellular signal transduction domain comprises an intracellular activation signal transduction domain and/or an intracellular detection signal transduction domain. The described chimeric antigen receptor-engineered NK cell has the advantages of both an immune checkpoint inhibitor and a CAR-engineered NK cell, and provides a solution for improving the treatment of solid tumors.

Inventors:
LI XIAODONG (CN)
Application Number:
PCT/CN2022/073311
Publication Date:
July 28, 2022
Filing Date:
January 21, 2022
Export Citation:
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Assignee:
NANJING HYOSKY ZHONGKE TECH DEVELOPMENT CO LTD (CN)
International Classes:
C12N5/10; A61K35/17; A61K48/00; A61P25/00; A61P31/00; A61P35/00; A61P37/00; C07K19/00; C12N7/01; C12N15/62; C12N15/867
Domestic Patent References:
WO2013123061A12013-08-22
Foreign References:
CN112279923A2021-01-29
CN112279922A2021-01-29
CN107988164A2018-05-04
CN110964697A2020-04-07
CN110079502A2019-08-02
CN112048481A2020-12-08
CN107759701A2018-03-06
CN109207430A2019-01-15
US20200129552A12020-04-30
CN112029729A2020-12-04
Other References:
FABIAN KELLSYE P, PADGET MICHELLE R, DONAHUE RENEE N., SOLOCINSKI KRISTEN, ROBBINS YVETTE, ALLEN CLINT T., LEE JOHN H., RABIZADEH : "PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effects and target suppressive MDSC populations", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 1 May 2020 (2020-05-01), pages e000450, XP055953974, DOI: 10.1136/jitc-2019-000450
GUO CHANGJIANG; WANG XIAOYIN; ZHANG HUIYONG; ZHI LINGTONG; LV TANYU; LI MINGFENG; LU CHENGUI; ZHU WULING: "Structure-based rational design of a novel chimeric PD1-NKG2D receptor for natural killer cells", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 114, 24 July 2019 (2019-07-24), GB , pages 108 - 113, XP085844149, ISSN: 0161-5890, DOI: 10.1016/j.molimm.2019.07.009
Attorney, Agent or Firm:
PERIODIC LAW FIRM (CN)
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