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Patent Searching and Data


Title:
CHIRAL PHOSPHINES, TRANSITION METAL COMPLEXES THEREOF AND USES THEREOF IN ASYMMETRIC REACTIONS
Document Type and Number:
WIPO Patent Application WO2001034612
Kind Code:
A3
Abstract:
Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include (R,S,S,R)-DIOP*. The ruthenium complex reduces enamide to the corresponding amine with up to 99% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.

Inventors:
ZHANG XUMU (US)
Application Number:
PCT/US2000/030889
Publication Date:
October 04, 2001
Filing Date:
November 10, 2000
Export Citation:
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Assignee:
PENN STATE RES FOUND (US)
ZHANG XUMU (US)
International Classes:
B01J31/24; C07B53/00; C07C231/18; C07F9/50; C07F9/553; C07F9/572; C07F9/6506; C07F9/655; C07F9/6561; C07F9/6596; C07C233/05; C07C233/13; C07C233/18; (IPC1-7): C07C69/34; C07C233/04; C07D319/04; C07D319/20; C07D407/02; C07D487/08; C07D493/06; C07F9/02; C07F9/28
Other References:
WIESAUER ET AL.: "Synthesis, determination of enantiomeric purity and structural characterization of enantiopure (2R,5R)-(+)-2,5-bis-(diphenylphosphino)-hexane, a chiral DPPB analogue", TETRAHEDRON ASYMMETRY, vol. 7, no. 2, 1996, pages 397 - 398, XP002938261
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