Title:
CHLORINATION METHOD FOR SUCROSE-6-CARBOXYLATE
Document Type and Number:
WIPO Patent Application WO/2022/140931
Kind Code:
A1
Abstract:
The present application provides a chlorination method for a sucrose-6-carboxylate, comprising: dissolving a solid phosgene into a first solvent to obtain a solid phosgene solution, and dissolving a sucrose-6-carboxylate into a second solvent to obtain a carboxylate solution, adding a catalyst to the carboxylate solution, and then slowly dropwise adding the solid phosgene solution into the carboxylate solution containing the catalyst at a first preset temperature, followed by operating the reactant mixing step a plurality of times to obtain a reaction mixture solution, maintaining the reaction mixture solution at the first preset temperature for a first preset time, and then heating same to a second preset temperature and maintaining the reaction for a second preset time for a chlorination reaction. The present application avoids the current situation of caking of the Vilsmeier reagent and DMF, improves the safety, reliability and environmental friendliness of the reaction, and reduces the reaction cost. In addition, the reaction conditions are mild, and the process is convenient to operate, the selectivity of the trichloride substance is high, the side reactions are few, and the yield of the product is high, and the discharge amount of waste gas and waste liquid is small.
Inventors:
ZHANG CONGYONG (CN)
ZHAO JINGANG (CN)
BU YONGFENG (CN)
CHEN CHAOHUI (CN)
ZHAO JINGANG (CN)
BU YONGFENG (CN)
CHEN CHAOHUI (CN)
Application Number:
PCT/CN2020/140221
Publication Date:
July 07, 2022
Filing Date:
December 28, 2020
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H13/06; C07H1/00
Foreign References:
| CN105111250A | 2015-12-02 | |||
| CN102417526A | 2012-04-18 | |||
| CN1660868A | 2005-08-31 | |||
| CN102167712A | 2011-08-31 | |||
| CN102070678A | 2011-05-25 | |||
| CN103087116A | 2013-05-08 | |||
| US20120184729A1 | 2012-07-19 | |||
| CN101177437A | 2008-05-14 | |||
| CN101768193A | 2010-07-07 |
Other References:
HU HAIWEI: "Study on Synthesis of Derivatives of Sucrose", CHINESE MASTER’S THESES FULL-TEXT DATABASE, ENGINEERING SCIENCE AND TECHNOLOGY I, 31 October 2006 (2006-10-31), XP055947415
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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