Title:
CHOLINE BITARTRATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/078408
Kind Code:
A1
Abstract:
A choline bitartrate and a preparation method therefor, pertaining to the technical field of chemical synthesis. First, tartaric acid and trimethylamine are reacted in a molar ratio of 0.8-1.2:2 to form trimethylamine tartrate, then ethylene oxide is added to the trimethylamine tartrate in a molar ratio of trimethylamine tartrate to ethylene oxide of 1:2 for reaction to generate dicholine tartrate, then tartaric acid is added to the dicholine tartrate in a molar ratio of dicholine tartrate to tartaric acid of 1:0.8-1.2, and finally, a white or colorless choline bitartrate finished product is obtained by concentration, crystallization, and drying. No methanol is used in the production process, avoiding the emission of volatile organic compounds (VOC) during the production process, and the product does not contain toxic and harmful substances such as methanol. The method uses easily available raw materials, involves stable reactions, is environmentally friendly, and has a yield of higher than 98.1%. The product has a uniform morphology and good stability, and has high application value in the fields of food nutritive fortifiers, pharmaceuticals, and feed additives.
Inventors:
WANG QINGYOU (CN)
WANG JIALIANG (CN)
LI MIN (CN)
ZHAO SHIZHANG (CN)
WANG JIALIANG (CN)
LI MIN (CN)
ZHAO SHIZHANG (CN)
Application Number:
PCT/CN2019/111617
Publication Date:
April 23, 2020
Filing Date:
October 17, 2019
Export Citation:
Assignee:
JINAN PENGBO BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C213/04; A61K31/14; A61P1/16
Domestic Patent References:
| WO2017165287A1 | 2017-09-28 |
Foreign References:
| EP0812821A1 | 1997-12-17 | |||
| CN109438268A | 2019-03-08 | |||
| CN108707082A | 2018-10-26 |
Other References:
ANONYMOUS: "New process for smell free cholinebitartrate", RESEARCH DISCLOSURE, vol. 465, no. 77, 31 January 2003 (2003-01-31), XP007132021
PEREIRA, J. B. ET AL.: "Molecular interactions in aqueous biphasic systems composed of polyethylene glycol and crystalline vs. liquid cholinium-based salts", PHYS.CHEM.CHEM.PHYS., vol. 16, 28 January 2014 (2014-01-28), pages 5723 - 5731, XP055703012
BISHT, M. ET AL.: "Long-term protein packaging in cholinium-based ionic liquids: improved catalytic activity and enhanced stability of cytochrome c against multiple stresses", GREEN CHEM., vol. 19, 5 September 2017 (2017-09-05), pages 4900 - 4911, XP055703016
XU, AIRONG ET AL.: "Efficient and sustainable solvents for lignin dissolution: aqueous choline carboxylate solutions", GREEN CHEM., vol. 19, 31 July 2017 (2017-07-31), pages 4067 - 4073, XP055630632, DOI: 10.1039/C7GC01886J
FUKAYA, Y. ET AL.: "Bio ionic liquids: room temperature ionic liquids composed wholly of biomaterials", GREEN CHEM., vol. 9, 16 July 2007 (2007-07-16), pages 1155 - 1157, XP055703020, DOI: 10.1039/b706571j
PEREIRA, J. B. ET AL.: "Molecular interactions in aqueous biphasic systems composed of polyethylene glycol and crystalline vs. liquid cholinium-based salts", PHYS.CHEM.CHEM.PHYS., vol. 16, 28 January 2014 (2014-01-28), pages 5723 - 5731, XP055703012
BISHT, M. ET AL.: "Long-term protein packaging in cholinium-based ionic liquids: improved catalytic activity and enhanced stability of cytochrome c against multiple stresses", GREEN CHEM., vol. 19, 5 September 2017 (2017-09-05), pages 4900 - 4911, XP055703016
XU, AIRONG ET AL.: "Efficient and sustainable solvents for lignin dissolution: aqueous choline carboxylate solutions", GREEN CHEM., vol. 19, 31 July 2017 (2017-07-31), pages 4067 - 4073, XP055630632, DOI: 10.1039/C7GC01886J
FUKAYA, Y. ET AL.: "Bio ionic liquids: room temperature ionic liquids composed wholly of biomaterials", GREEN CHEM., vol. 9, 16 July 2007 (2007-07-16), pages 1155 - 1157, XP055703020, DOI: 10.1039/b706571j
Attorney, Agent or Firm:
HEFEI GUOHE PATENT AGENCY (GENERAL PARTNERSHIP) et al. (CN)
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