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Title:
CHROMOGENIC SUBSTRATES OF SIALIDASE OF BACTERIAL, VIRAL, PROTOZOA, AND VERTEBRATE ORIGIN AND METHODS OF MAKING AND USING THE SAME
Document Type and Number:
WIPO Patent Application WO2001025246
Kind Code:
A3
Abstract:
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

Inventors:
JOHNSON STEPHEN C
LUO MING
YAN SHIJIA
Application Number:
PCT/US2000/027505
Publication Date:
November 29, 2001
Filing Date:
October 05, 2000
Export Citation:
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Assignee:
IBBEX INC (US)
UAB RESEARCH FOUNDATION (US)
International Classes:
C07H7/027; C07H15/203; C07H15/24; C07H15/26; C07H17/02; C07H17/075; C12Q1/34; C12R1/93; (IPC1-7): C07H15/203; C07H15/26; C07H17/02; C07H17/075; C12N9/24; C12Q1/34
Domestic Patent References:
WO1991009975A11991-07-11
WO2000024753A12000-05-04
Foreign References:
US5663055A1997-09-02
Other References:
F. BAUMBERGER ET AL.: "208. 4-Methylumbelliferyl 5-acetamido-3,4,5-trideoxy-alfa-D-manno-2-nonulopyranosidonic acid: Synthesis and resistance to bacterial sialidases", HELVETICA CHIMICA ACTA, vol. 69, 1986, pages 1927 - 1935, XP002163908
E. ZBIRAL ET AL.: "Synthesis of the 4-methylumbelliferyl 2-alfa-glycosides of 7-epi-, 8-epi-, and 7,8-bis(epi)-N-acetylneuraminic acids, as well as of 7-deoxy-, 8-deoxy-, 9-deoxy-, and 4,7-dideoxy-N-acetylneuraminic acids and their behaviour towards sialidase from Vibrio cholerae", LIEBIGS ANN. CHEM., 1989, pages 519 - 526, XP002163909
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