Title:
COCOA EXTRACT COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME
Document Type and Number:
WIPO Patent Application WO1997036497
Kind Code:
A3
Abstract:
Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a polymeric compound of the formula A n , wherein A is a monomer of formula (I) wherein n is an integer from 2 to 18, such that there is at least one terminal monomeric unit A, and one or a plurality of additional monomeric units; R is 3-(±)-OH, 3-(²)-OH, 3-(±)-O-sugar or 3-(²)-O sugar; bonding between adjacent monomers takes place at positions 4, 6 or 8; a bond of an additional monomeric unit in position 4 has alpha or beta stereochemistry; X, Y and Z are selected from the group consisting of monomeric unit A, hydrogen, and a sugar, with the provisos that as to the at least one terminal monomeric unit, bonding of the additional monomeric unit thereto (the bonding of the additional monomeric unit adjacent to the terminal monomeric unit) is at position 4 and optionally Y = Z = hydrogen; the sugar is optionally substituted with a phenolic moiety, at any position on the sugar, for instance via an ester bond; and pharmaceutically acceptable salts or derivatives thereof (including oxidation products).
Inventors:
ROMANCZYK LEO J JR (US)
HAMMERSTONE JOHN F JR (US)
BUCK MARGARET M (US)
POST LAURIE S (US)
CIPOLLA GIOVANNI G (US)
MCCLELLAND CRAIG A (US)
MUNDT JEFF A (US)
SCHMITZ HAROLD H (US)
HAMMERSTONE JOHN F JR (US)
BUCK MARGARET M (US)
POST LAURIE S (US)
CIPOLLA GIOVANNI G (US)
MCCLELLAND CRAIG A (US)
MUNDT JEFF A (US)
SCHMITZ HAROLD H (US)
Application Number:
PCT/US1997/005693
Publication Date:
December 24, 1997
Filing Date:
April 02, 1997
Export Citation:
Assignee:
MARS INC (US)
ROMANCZYK LEO J JR (US)
HAMMERSTONE JOHN F JR (US)
BUCK MARGARET M (US)
POST LAURIE S (US)
CIPOLLA GIOVANNI G (US)
MCCLELLAND CRAIG A (US)
MUNDT JEFF A (US)
SCHMITZ HAROLD H (US)
ROMANCZYK LEO J JR (US)
HAMMERSTONE JOHN F JR (US)
BUCK MARGARET M (US)
POST LAURIE S (US)
CIPOLLA GIOVANNI G (US)
MCCLELLAND CRAIG A (US)
MUNDT JEFF A (US)
SCHMITZ HAROLD H (US)
International Classes:
A23G1/30; A23G1/00; A61K9/20; A61K9/28; A61K31/00; A61K31/365; A61K31/366; A61K31/70; A61K31/7012; A61K31/7042; A61K31/7048; A61P1/00; A61P1/02; A61P3/00; A61P3/06; A61P3/08; A61P7/00; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P37/00; A61P37/02; A61P39/00; A61P39/06; A61P43/00; C07D311/62; C07H17/06; C07H17/065; C12Q1/00; C12Q1/02; G01N33/50; G01N33/52; (IPC1-7): A23G/
Foreign References:
EP0657169A1 | 1995-06-14 | |||
US4166861A | 1979-09-04 |
Other References:
JOURNAL CHEMICAL SOCIETY, PERKINS TRANSACTIONS I, 1980, Vol. 10, CZOCHANSKA et al., "Polymeric Proantocyanidins. Stereochemistry, Structural Units and Molecular Weight", pages 2278-2286.
BIOCHEMICAL JOURNAL, 1992, Vol. 282, AUSTIN et al., "Site-Specific DNA Cleavage by Mammalian DNA Topoisomerase II Induced by Novel Flavone and Catechin Derivatives", pages 883-889.
JOURNAL OF PHARMACEUTICAL SCIENCES, May 1993, Vol. 82, No. 5, KASHIWADA et al., "Tannins as Potential Inhibitors of DNA Topoisomerase II In Vitro", pages 487-492.
PLANTA MEDICA, 1994, Vol. 60, GALI et al., "Comparison of the Inhibitory Effects of Monomeric, Dimeric and Trimeric Procyanidins on the Biochemical Markers of Skin Tumor Promotion in Mouse Epidermis in Vivo", pages 235-239.
JOURNAL OF NATURAL PRODUCTS, February 1995, Vol. 58, No. 2, CONSTANTINOU et al., "Flavanoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships", pages 217-225.
See also references of EP 1015006A4
BIOCHEMICAL JOURNAL, 1992, Vol. 282, AUSTIN et al., "Site-Specific DNA Cleavage by Mammalian DNA Topoisomerase II Induced by Novel Flavone and Catechin Derivatives", pages 883-889.
JOURNAL OF PHARMACEUTICAL SCIENCES, May 1993, Vol. 82, No. 5, KASHIWADA et al., "Tannins as Potential Inhibitors of DNA Topoisomerase II In Vitro", pages 487-492.
PLANTA MEDICA, 1994, Vol. 60, GALI et al., "Comparison of the Inhibitory Effects of Monomeric, Dimeric and Trimeric Procyanidins on the Biochemical Markers of Skin Tumor Promotion in Mouse Epidermis in Vivo", pages 235-239.
JOURNAL OF NATURAL PRODUCTS, February 1995, Vol. 58, No. 2, CONSTANTINOU et al., "Flavanoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships", pages 217-225.
See also references of EP 1015006A4
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