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Patent Searching and Data


Title:
COCRYSTAL OF TOCOPHEROL AND PROLINE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/128175
Kind Code:
A1
Abstract:
Disclosed are a cocrystal of tocopherol and proline and a preparation method therefor. The cocrystal is in crystalline or partially crystalline form in the environment of normal pressure and room temperature. Compared to the existing tocopherols, the cocrystal has a higher melting point and a better degree of crystallinity, and possesses a better high temperature stability, stability against light irradiation, accelerated stability and long-term stability. Healthcare products, food, cosmetics or feed products prepared with the cocrystal have a significantly improved stability. The cocrystal maintains excellent antioxidant properties of tocopherols, and can be extensively used in fields of food, medicine, etc. as an antioxidant. The present invention greatly improves the use convenience of tocopherols, and saves on the cost during the processes of manufacture, storage, transportation and use.

Inventors:
MEI XUEFENG (CN)
ZHU BINGQING (CN)
WANG JIANRONG (CN)
ZHANG QI (CN)
Application Number:
PCT/CN2018/093967
Publication Date:
July 04, 2019
Filing Date:
July 02, 2018
Export Citation:
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Assignee:
COCRYSTAL PHARMACEUTICAL TECH SHANGHAI CO LTD (CN)
International Classes:
C07D311/72; A23K20/121; A23K20/142; A23K20/174; A23L33/15; A23L33/175; A61K31/401; A61P39/06; C07D207/16
Domestic Patent References:
WO2008010362A12008-01-24
Foreign References:
CN1477959A2004-02-25
JP2008024603A2008-02-07
Other References:
See also references of EP 3733657A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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