Title:
CODRUG THAT DISINTEGRATES IN INTESTINE, PREPARATION THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/012693
Kind Code:
A1
Abstract:
The present invention relates to a codrug that disintegrates in the intestine, preparation therefor, and a use thereof. Specifically, provided is a codrug compound in formula I. Also provided are a method of using the present compound for the treatment of gastrointestinal tract autoimmune diseases, inflammatory diseases, and cancers, as well as a method and an intermediate for preparing the present compound.
Inventors:
SHOU JIANYONG (CN)
AO XIANG (CN)
JIANG LEI (CN)
LIU SHENGYANG (CN)
MAO XUDONG (CN)
QIAO ZHI (CN)
XIE XIAOPING (CN)
ZHANG JIANHUA (CN)
AO XIANG (CN)
JIANG LEI (CN)
LIU SHENGYANG (CN)
MAO XUDONG (CN)
QIAO ZHI (CN)
XIE XIAOPING (CN)
ZHANG JIANHUA (CN)
Application Number:
PCT/CN2021/107208
Publication Date:
January 20, 2022
Filing Date:
July 19, 2021
Export Citation:
Assignee:
ENNOVABIO ZHEJIANG PHARMACEUTICALS CO LTD (CN)
SHANGHAI ENNOVABIO PHARMACEUTICALS CO LTD (CN)
SHANGHAI ENNOVABIO PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D455/03; A61K31/4375; A61K31/519; A61P1/04
Domestic Patent References:
| WO1995020567A1 | 1995-08-03 |
Foreign References:
| CN107613768A | 2018-01-19 | |||
| CN108272802A | 2018-07-13 | |||
| TW201742863A | 2017-12-16 | |||
| EP2651864B1 | 2016-07-13 |
Other References:
ALJUFFALI IBRAHIM A., LIN CHWAN-FWU, CHEN CHUN-HAN, FANG JIA-YOU: "The codrug approach for facilitating drug delivery and bioactivity", EXPERT OPINION ON DRUG DELIVERY, INFORMA HEALTHCARE, GB, vol. 13, no. 9, 1 September 2016 (2016-09-01), GB , pages 1311 - 1325, XP055887223, ISSN: 1742-5247, DOI: 10.1080/17425247.2016.1187598
DAS, N. ; DHANAWAT, M. ; DASH, B. ; NAGARWAL, R.C. ; SHRIVASTAVA, S.K.: "Codrug: An efficient approach for drug optimization", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 41, no. 5, 23 December 2010 (2010-12-23), NL , pages 571 - 588, XP027493532, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2010.09.014
"Chiral Separations, Methods and Protocols", METHODS IN MOLECULAR BIOLOGY, vol. 243, 2004
A.M. STALCUP: "Chiral Separations", ANNU. REV. ANAL. CHEM., vol. 3, 2010, pages 341 - 63
FUMISS ET AL.: "VOGEL'S ENCYCLOPEDIA OF PRACTICAL ORGANIC CHEMISTRY", 1991, LONGMAN SCIENTIFIC AND TECHNICAL LTD., pages: 809 - 816
HELLER, ACC. CHEM. RES., vol. 23, 1990, pages 128
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", MACK PUBLISHING CO.
DAS, N. ; DHANAWAT, M. ; DASH, B. ; NAGARWAL, R.C. ; SHRIVASTAVA, S.K.: "Codrug: An efficient approach for drug optimization", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 41, no. 5, 23 December 2010 (2010-12-23), NL , pages 571 - 588, XP027493532, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2010.09.014
"Chiral Separations, Methods and Protocols", METHODS IN MOLECULAR BIOLOGY, vol. 243, 2004
A.M. STALCUP: "Chiral Separations", ANNU. REV. ANAL. CHEM., vol. 3, 2010, pages 341 - 63
FUMISS ET AL.: "VOGEL'S ENCYCLOPEDIA OF PRACTICAL ORGANIC CHEMISTRY", 1991, LONGMAN SCIENTIFIC AND TECHNICAL LTD., pages: 809 - 816
HELLER, ACC. CHEM. RES., vol. 23, 1990, pages 128
GOODMANGILMAN: "The Pharmacological Basis of Therapeutics", MACK PUBLISHING CO.
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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