Title:
COLOUR TUNABLE LUMINESCENT BIDENTATE PLATINUM (II) COMPLEXES FOR PROBING MISMATCH DNA
Document Type and Number:
WIPO Patent Application WO/2021/052207
Kind Code:
A1
Abstract:
Pertains to the design and applications of platinum (II) compounds supported by a bidentate and N-heterocyclic carbene ligands. The Pt (II) complexes exhibit strong emission intensity differences when contacted with matched and mismatched DNA. In addition, the Pt (II) complexes show a color tunable effect when exposed to mismatched compared to matched DNA, which color effect can be easily detected.
Inventors:
CHE CHI MING (CN)
ZHANG MING (CN)
LOK CHUN NAM (CN)
ZHANG MING (CN)
LOK CHUN NAM (CN)
Application Number:
PCT/CN2020/113745
Publication Date:
March 25, 2021
Filing Date:
September 07, 2020
Export Citation:
Assignee:
UNIV HONG KONG (CN)
International Classes:
C07F17/02; C12Q1/68
Domestic Patent References:
| WO2016206583A1 | 2016-12-29 | |||
| WO2009118475A2 | 2009-10-01 |
Other References:
MAKAROVA ANNA A., GRACHOVA ELENA V., NIEDZIALEK DOROTA, SOLOMATINA ANASTASIA I., SONNTAG SIMON, FEDOROV ALEXANDER V., VILKOV OLEG : "A curious interplay in the films of N-heterocyclic carbene PtII complexes upon deposition of alkali metals", SCIENTIFIC REPORTS, vol. 6, no. 1, 1 July 2016 (2016-07-01), XP055793123, DOI: 10.1038/srep25548
GRAZIOTTO， M. E. ET AL.: "The influence of the ethane-1，2-diamine ligand on the activity of a monofunctional platinum complex.", JOURNAL OF INORGANIC BIOCHEMISTRY., vol. 177, 29 July 2017 (2017-07-29), pages 328 - 334, XP085311253, DOI: 20201118140646X
OKADA， T. ET AL.: "Mononuclear Platinum(II) Complex with 2-Phenylpyridine Ligands Showing High Cytotoxicity against Mouse Sarcoma 180 Cells Acquiring High Cisplatin Resistance.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 26, 15 November 2001 (2001-11-15), pages 4661 - 4667, XP055793126
GABR， M.T. ET AL.: "Platinum(II) Complexes with Sterically Expansive Tetraarylethylene Ligands as Probes for Mismatched DNA.", INORG. CHEM., vol. 57, 27 September 2018 (2018-09-27), pages 12641 - 12649, XP055793127
GRAZIOTTO， M. E. ET AL.: "The influence of the ethane-1，2-diamine ligand on the activity of a monofunctional platinum complex.", JOURNAL OF INORGANIC BIOCHEMISTRY., vol. 177, 29 July 2017 (2017-07-29), pages 328 - 334, XP085311253, DOI: 20201118140646X
OKADA， T. ET AL.: "Mononuclear Platinum(II) Complex with 2-Phenylpyridine Ligands Showing High Cytotoxicity against Mouse Sarcoma 180 Cells Acquiring High Cisplatin Resistance.", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 26, 15 November 2001 (2001-11-15), pages 4661 - 4667, XP055793126
GABR， M.T. ET AL.: "Platinum(II) Complexes with Sterically Expansive Tetraarylethylene Ligands as Probes for Mismatched DNA.", INORG. CHEM., vol. 57, 27 September 2018 (2018-09-27), pages 12641 - 12649, XP055793127
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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