Title:
COMBINATION THERAPY OF CYCLOSERINE AND LITHIUM FOR THE TREATMENT OF DEPRESSION
Document Type and Number:
WIPO Patent Application WO/2021/107690
Kind Code:
A1
Abstract:
The present invention relates to a combination therapy of cycloserine and lithium for the prevention or treatment of depression. The combined administration of cycloserine and lithium according to the present invention has a remarkably excellent effect of preventing or treating depression compared to each single administration, thereby being effectively utilized as a combination therapy for antidepressants.
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Inventors:
LEE SUKCHAN (KR)
CHI YONG HA (KR)
JANG DONG CHEOL (KR)
KWON GIBEOM (KR)
CHI YONG HA (KR)
JANG DONG CHEOL (KR)
KWON GIBEOM (KR)
Application Number:
PCT/KR2020/017101
Publication Date:
June 03, 2021
Filing Date:
November 27, 2020
Export Citation:
Assignee:
NEURORIVE INC (KR)
International Classes:
A61K31/42; A23L33/10; A23L33/16; A61K33/14; A61P25/24; A61P25/28
Domestic Patent References:
| WO2008118785A2 | 2008-10-02 |
Other References:
ROUAUD E, BILLARD J-M: "-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices : -cycloserine in CA1 hippocampal activity", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 140, no. 6, 1 November 2003 (2003-11-01), UK, pages 1051 - 1056, XP055815149, ISSN: 0007-1188, DOI: 10.1038/sj.bjp.0705541
JOLLANT FABRICE,: "Add-on lithium for the treatment of unipolar depression: Too often forgotten?", JOURNAL OF PSYCHIATRY AND NEUROSCIENCE., OTTAWA., CA, vol. 40, no. 1, 1 January 2015 (2015-01-01), CA, pages E23 - E24, XP055815147, ISSN: 1180-4882, DOI: 10.1503/jpn.140162
LENER MARC S., KADRIU BASHKIM, ZARATE CARLOS A.: "Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression", DRUGS, ADIS INTERNATIONAL LTD., NZ, vol. 77, no. 4, 1 March 2017 (2017-03-01), NZ, pages 381 - 401, XP055815145, ISSN: 0012-6667, DOI: 10.1007/s40265-017-0702-8
CHEN MU-HONG; CHENG CHIH-MING; GUEORGUIEVA RALITZA; LIN WEI-CHEN; LI CHENG-TA; HONG CHEN-JEE; TU PEI-CHI; BAI YA-MEI; TSAI SHIH-JE: "Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo–control study", NEUROPSYCHOPHARMACOLOGY., ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 44, no. 12, 17 August 2019 (2019-08-17), US, pages 2112 - 2118, XP036906184, ISSN: 0893-133X, DOI: 10.1038/s41386-019-0480-y
JOLLANT FABRICE,: "Add-on lithium for the treatment of unipolar depression: Too often forgotten?", JOURNAL OF PSYCHIATRY AND NEUROSCIENCE., OTTAWA., CA, vol. 40, no. 1, 1 January 2015 (2015-01-01), CA, pages E23 - E24, XP055815147, ISSN: 1180-4882, DOI: 10.1503/jpn.140162
LENER MARC S., KADRIU BASHKIM, ZARATE CARLOS A.: "Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression", DRUGS, ADIS INTERNATIONAL LTD., NZ, vol. 77, no. 4, 1 March 2017 (2017-03-01), NZ, pages 381 - 401, XP055815145, ISSN: 0012-6667, DOI: 10.1007/s40265-017-0702-8
CHEN MU-HONG; CHENG CHIH-MING; GUEORGUIEVA RALITZA; LIN WEI-CHEN; LI CHENG-TA; HONG CHEN-JEE; TU PEI-CHI; BAI YA-MEI; TSAI SHIH-JE: "Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo–control study", NEUROPSYCHOPHARMACOLOGY., ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 44, no. 12, 17 August 2019 (2019-08-17), US, pages 2112 - 2118, XP036906184, ISSN: 0893-133X, DOI: 10.1038/s41386-019-0480-y
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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