COMBINATION THERAPY FOR THE TREATMENT OF ESTROGEN-RECEPTOR POSITIVE BREAST CANCER

Title:

COMBINATION THERAPY FOR THE TREATMENT OF ESTROGEN-RECEPTOR POSITIVE BREAST CANCER

Document Type and Number:

WIPO Patent Application WO/2020/053664

Kind Code:

A8

Abstract:

Methods for treating estrogen receptor positive (ER+) breast cancer, comprising administering to a subject in need thereof, a BET bromodomain inhibitor in combination with a second agent, selected from a selective-estrogen receptor degrader (SERD), a selective-estrogen receptor modulator (SERM) and a selective CDK4/6 inhibitor. The BET bromodomain inhibitor is selected from 1-benzyl-6-(3,5-dimethylisoxazol-4-yl)-N-methyl-1H-imidazo[4,5-b]pyridin-2-amine (Compound I), 1-benzyl-6-(3,5-dimethylisoxazol-4-yl)-1H-imidazo [4,5-b]pyridin-2-amine, and pharmaceutically acceptable salts/co-crystals thereof.

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Inventors:

CAMPEAU ERIC (CA)
KHARENKO OLESYA (CA)
VAN DER HORST EDWARD (US)

Application Number:

PCT/IB2019/001035

Publication Date:

May 07, 2020

Filing Date:

September 13, 2019

Export Citation:

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Assignee:

ZENITH EPIGENETICS LTD (CA)

International Classes:

A61K31/437; A61K31/506; A61K31/519; A61K31/565; A61P35/00; C07D401/14; C07D471/04; C07D487/04; C07J31/00

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