Title:
COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
Document Type and Number:
WIPO Patent Application WO1998049315
Kind Code:
A3
Abstract:
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
Inventors:
KHOSLA CHAITAN
ASHLEY GARY
FU HONG
KAO CAMILLA M
MCDANIEL ROBERT
ASHLEY GARY
FU HONG
KAO CAMILLA M
MCDANIEL ROBERT
Application Number:
PCT/US1998/008792
Publication Date:
January 14, 1999
Filing Date:
April 30, 1998
Export Citation:
Assignee:
KOSAN BIOSCIENCES INC (US)
UNIV LELAND STANFORD JUNIOR (US)
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
A61K31/335; A61K31/351; A61K31/7048; A61P31/04; C07D309/10; C07D309/30; C07D309/32; C07D313/00; C07D313/18; C12N15/09; C07D323/00; C07D493/10; C07H17/04; C07H17/08; C12M1/00; C12N1/21; C12N15/52; C12P17/06; C07B61/00; (IPC1-7): C12N15/52; C12N15/76; C12N9/00; C12N1/21; C12P17/06; C07D309/00; C07D313/04; C07D493/10; C07D313/00; C07H17/04
Domestic Patent References:
| WO1996040968A1 | 1996-12-19 |
Other References:
KHOSLA C ET AL: "Generation of polyketide libraries via combinatorial biosynthesis.", TRENDS BIOTECHNOL, SEP 1996, 14 (9) P335-41, ENGLAND, XP004035738
KAO CM ET AL: "Engineered biosynthesis of a complete macrolactone in a heterologous host.", SCIENCE, JUL 22 1994, 265 (5171) P509-12, UNITED STATES, XP002073974
KAO CM ET AL: "Engineered biosynthesis of a complete macrolactone in a heterologous host.", SCIENCE, JUL 22 1994, 265 (5171) P509-12, UNITED STATES, XP002073974
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