Title:
COMPOSITE PHARMACEUTICAL COMPOSITION FOR TREATMENT OF BRAIN DISEASE, COMPRISING CHOLINESTERASE INHIBITOR AND ANTIOXIDANT
Document Type and Number:
WIPO Patent Application WO/2022/163971
Kind Code:
A1
Abstract:
The present invention relates to a composite pharmaceutical composition for the treatment of brain disease, comprising a cholinesterase inhibitor and an antioxidant, and more specifically to a composition for the prevention or treatment of brain disease, comprising: a cholinesterase inhibitor exhibiting a synergistic effect in neuronal protection and the promotion of neuronal differentiation; and an antioxidant.
Inventors:
LEE JI HYUN (KR)
KIM EUN JUNG (KR)
KIM EUN JUNG (KR)
Application Number:
PCT/KR2021/015350
Publication Date:
August 04, 2022
Filing Date:
October 28, 2021
Export Citation:
Assignee:
DR NOAH BIOTECH INC (KR)
International Classes:
A61K31/445; A23L33/10; A61K31/198; A61P9/10; A61P25/28
Foreign References:
| JP4373087B2 | 2009-11-25 | |||
| KR20190129000A | 2019-11-19 | |||
| US20020128319A1 | 2002-09-12 | |||
| KR20210012659A | 2021-02-03 |
Other References:
YANG XIN, WEI HAN‑MEI, HU GUO‑YAN, ZHAO JUN, LONG LI‑NA, LI CHANG‑JIAN, ZHAO ZI‑JUN, ZENG HE‑KUN, NIE HONG: "Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 21, 1 January 2020 (2020-01-01), GR , pages 1043 - 1050, XP055954377, ISSN: 1791-2997, DOI: 10.3892/mmr.2020.10920
CORNELLI UMBERTO, CORNELLI UMBERTO: "Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants", NEURODEGENERATIVE DISEASES, KARGER, CH, vol. 7, no. 1-3, 1 January 2010 (2010-01-01), CH , pages 193 - 202, XP055954380, ISSN: 1660-2854, DOI: 10.1159/000295663
KIRINO TSANO K., ACTA NEUROPATHOL, vol. 62, 1984, pages 201 - 208
KIRINO T., BRAIN RES., vol. 239, 1982, pages 57 - 69
KANG TC ET AL., J. NEUROCYTOL, vol. 30, 2001, pages 945 - 955
WON MH ET AL., BRAIN RES, vol. 836, 1999, pages 70 - 78
SUB AY.CHEN 1'M., J. BIOMED. SCI., vol. 5, 1998, pages 401 - 414
FLOWERS FZIMMERMAN JJ, NEW HORIZ, vol. 6, 1998, pages 169 - 180
EHRLICH ET AL.: "PSD-95 is required for activity-driven synapse stabilization", PNAS, 2007
NAGURA ET AL.: "Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding deficient PSD-95 knockin mice", MOLECULAR BRAIN, 2012
MIZUNO ET AL.: "CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning", BEHAVIOURAL BRAIN RESEARCH, 2002
KIDA ET AL.: "Functional roles of CREB as a positive regulator in the formation and enhanced of memory", BRAIN RESEARCH BULLETIN, 2014
CORNELLI UMBERTO, CORNELLI UMBERTO: "Treatment of Alzheimer’s Disease with a Cholinesterase Inhibitor Combined with Antioxidants", NEURODEGENERATIVE DISEASES, KARGER, CH, vol. 7, no. 1-3, 1 January 2010 (2010-01-01), CH , pages 193 - 202, XP055954380, ISSN: 1660-2854, DOI: 10.1159/000295663
KIRINO TSANO K., ACTA NEUROPATHOL, vol. 62, 1984, pages 201 - 208
KIRINO T., BRAIN RES., vol. 239, 1982, pages 57 - 69
KANG TC ET AL., J. NEUROCYTOL, vol. 30, 2001, pages 945 - 955
WON MH ET AL., BRAIN RES, vol. 836, 1999, pages 70 - 78
SUB AY.CHEN 1'M., J. BIOMED. SCI., vol. 5, 1998, pages 401 - 414
FLOWERS FZIMMERMAN JJ, NEW HORIZ, vol. 6, 1998, pages 169 - 180
EHRLICH ET AL.: "PSD-95 is required for activity-driven synapse stabilization", PNAS, 2007
NAGURA ET AL.: "Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding deficient PSD-95 knockin mice", MOLECULAR BRAIN, 2012
MIZUNO ET AL.: "CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning", BEHAVIOURAL BRAIN RESEARCH, 2002
KIDA ET AL.: "Functional roles of CREB as a positive regulator in the formation and enhanced of memory", BRAIN RESEARCH BULLETIN, 2014
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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