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Title:
COMPOSITE PRODUCT CONTAINING LIMONIN COMPOUND AND BIGUANIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/029319
Kind Code:
A1
Abstract:
The present invention relates to a composition containing a limonin compound and a pharmaceutically acceptable derivative, ester, stereoisomer, salt or prodrug thereof and a biguanide compound; the biguanide compound may be metformin or metformin hydrochloride, buformin or phenformin, and so on. The present invention further relates to a use of the composition in the treatment and/or prevention of diseases associated with diabetes, fat-reduction weight loss and so on.

Inventors:
LI DONG (CN)
HAN QUAN (CN)
HU LIU (CN)
XUE LIAN (CN)
Application Number:
PCT/CN2018/095615
Publication Date:
February 14, 2019
Filing Date:
July 13, 2018
Export Citation:
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Assignee:
ZHEJIANG YANGSHENGTANG INST OF NATURAL MEDICATION CO LTD (CN)
International Classes:
A61K31/366; A61K31/155; A61P3/04; A61P3/10; C07J73/00
Domestic Patent References:
WO2014049366A12014-04-03
WO2014203059A12014-12-24
Foreign References:
CN103597071A2014-02-19
CN103402358A2013-11-20
CN102481276A2012-05-30
CN106132425A2016-11-16
CN101330921A2008-12-24
Other References:
CHONGDE ET AL: "extraction,identification and determination of natural limonin and nomolin from citrus fruits", JOURNAL OF CHINESE INSTITUTE OF FOOD SCIENCE AND TECHNOLOGY, vol. 4, no. 1, 31 March 2014 (2014-03-31), pages 6 - 11, XP055658776, DOI: 10.16429/j.1009.2001.01.02
LI NAN ET AL.: "Protective effect of pine pollen on kidney damage in diabetic nephropathy mice", SCIENCE AND TECHNOLOGY REVIEW, vol. 32, no. 4/5, 2014, pages 95 - 99
ZHANG JIYUAN ET AL.: "Study on the effect of three plant extracts on improving glucose and lipid metabolism in type 2 diabetic mice", FOOD AND MACHINERY, vol. 32, no. 12, 2016, pages 142 - 147
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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