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Patent Searching and Data


Title:
COMPOSITION FOR AUGMENTING STEMNESS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/071289
Kind Code:
A3
Abstract:
The present application pertains to a sialyloligosaccharide for augmenting the stemness of stem cells and a use thereof and provides a composition for augmenting stemness of stem cells, a method for culturing stem cells in a medium containing a sialyloligosaccharide, a method for augmenting stemness of stem cells, a stem cell with augmented stemness, obtained by the method, and a cell therapy composition comprising the stem cells as an active ingredient. The composition or the method according to an aspect can suppress the aging of stem cells and can maintain and augment stemness.

Inventors:
KIM SUNG HOON (KR)
BAEK AH REUM (KR)
CHO SUNG RAE (KR)
WOO JIN SUK (KR)
KIM LI LA (KR)
KIM DAE HEE (KR)
Application Number:
PCT/KR2020/013745
Publication Date:
June 10, 2021
Filing Date:
October 08, 2020
Export Citation:
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Assignee:
GENECHEM INC (KR)
UNIV INDUSTRY FOUNDATION YONSEI UNIV WONJU CAMPUS (KR)
UNIV YONSEI IACF (KR)
International Classes:
C12N5/00; A61K35/28; A61K48/00; C12N5/071; C12N5/0775
Foreign References:
KR20120089915A2012-08-16
KR20180053461A2018-05-23
KR20160089110A2016-07-27
Other References:
ANTONELLA SGAMBATO, RUSSO LAURA, MONTESI MONICA, PANSERI SILVIA, MARCACCI MAURILIO, CARAVĂ€ ELENA, RASPANTI MARIO, CIPOLLA LAURA: "Different Sialoside Epitopes on Collagen Film Surfaces Direct Mesenchymal Stem Cell Fate", APPLIED MATERIALS & INTERFACES, vol. 8, no. 24, 23 December 2015 (2015-12-23), US, pages 14952 - 14957, XP055504376, ISSN: 1944-8244, DOI: 10.1021/acsami.5b08270
WANG CHENYUAN, ZHANG MING, GUO HUIYUAN, YAN JINGYU, LIU FAN, CHEN JIANLIANG, LI YIRAN, REN FAZHENG: "Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Inhibiting Intestinal Damage via Increasing the Proliferation of Crypt Cells", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 63, no. 18, 1 September 2019 (2019-09-01), DE, pages 1900262, XP055819259, ISSN: 1613-4125, DOI: 10.1002/mnfr.201900262
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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