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Title:
COMPOSITION COMPRISING (7S)-(+)-CYCLOPENTYL CARBARMIC ACID, 8,8-DIMETHYL-2-OXO-6,7-DIHYDRO-2H,8H-PYRANO[3,2-G]CHROMEN-7-YL-ESTER AS ACTIVE INGREDIENT FOR PREVENTION, ALLEVIATION, OR TREATMENT OF EYE DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/154356
Kind Code:
A1
Abstract:
The present disclosure relates to a composition comprising (7S)-(+)-cyclopentyl carbarmic acid, 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester as an active ingredient for prevention, alleviation, or treatment of eye disease. The (7S)-(+)-cyclopentyl carbarmic acid, 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester of the present disclosure exhibits the effect of remarkably reducing intraocular vascular leakage and as such, can be advantageously used in a composition for prevention, alleviation, or treatment of eye disease.

Inventors:
OH SANG TAEK (KR)
Application Number:
PCT/KR2022/000112
Publication Date:
July 21, 2022
Filing Date:
January 05, 2022
Export Citation:
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Assignee:
UNIV KOOKMIN IND ACAD COOP FOUND (KR)
International Classes:
A61K31/27; A23L33/10; A61K9/00; A61K31/366; A61P27/02
Foreign References:
KR101674145B12016-11-08
JP2012525415A2012-10-22
KR102338093B12021-12-10
Other References:
YANG YING; YANG KE; LI YIPING; LI XIANLI; SUN QIANGMING; MENG HUA; ZENG YING; HU YONG; ZHANG YING: "Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 378, no. 1, 1 January 1900 (1900-01-01), IE , pages 46 - 52, XP028726343, ISSN: 0303-7207, DOI: 10.1016/j.mce.2013.04.021
KIM JEONG HUN, KIM JIN HYOUNG, LEE YOU MIE, AHN EUN-MI, KIM KYU-WON, YU YOUNG SUK: "Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation", MOLECULAR VISION, MOLECULAR VISION, UNITED STATES, 12 September 2009 (2009-09-12), United States, pages 1868 - 1875, XP055950055, Retrieved from the Internet
KIM JIN HYOUNG, KIM JEONG HUN, LEE YOU MIE, AHN EUN-MI, KIM KYU-WON, YU YOUNG SUK: "Decursin Inhibits VEGF-Mediated Inner Blood—Retinal Barrier Breakdown by Suppression of VEGFR-2 Activation", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, NATURE PUBLISHING GROUP, US, vol. 29, no. 9, 1 September 2009 (2009-09-01), US , pages 1559 - 1567, XP055950031, ISSN: 0271-678X, DOI: 10.1038/jcbfm.2009.78
YANOFFDUKER: "Ophthalmology", 1999, MOSBY
WILKINSON ET AL.: "Michel's Retinal Detachment", 1997, MOSBY
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
"Remington's Pharmaceutical Science", 1975, MACK PUBLISHING COMPANY, pages: 18042
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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