Title:
COMPOSITION COMPRISING EMP3 INHIBITOR FOR INHIBITING GROWTH OF CANCER STEM CELL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/075853
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting the growth of cancer stem cells and a use thereof. When treated with the EMP3 inhibitor, cancer stem cells expressing ALDH1 decrease in self-renewal potential, invasiveness, and migration ability and thus are restrained from growing, whereby cancer having stemness properties, which are resistant to conventional anticancer therapies, can be effectively treated.
Inventors:
KIM IN GYU (KR)
KIM RAE KWON (KR)
KAHM YEON JEE (KR)
KIM RAE KWON (KR)
KAHM YEON JEE (KR)
Application Number:
PCT/KR2020/014018
Publication Date:
April 22, 2021
Filing Date:
October 14, 2020
Export Citation:
Assignee:
KOREA ATOMIC ENERGY RES (KR)
International Classes:
A61K48/00; A61K31/7088; A61K31/713; A61K39/395; A61K41/00; A61P35/00
Foreign References:
| KR20160026624A | 2016-03-09 |
Other References:
AKBAR, M. W.: "Characterization of chemosensitivity profiles of breast cancer cell lines, with and without stem cell like features.", MASTER'S THESIS, BILKENT UNIVERSITY, 1 August 2014 (2014-08-01), pages 1 - 123, XP055801060, [retrieved on 20210504]
HONG XIAO CHUN, FEN YUAN JIAN, YAN GUO CHUN, HONG HONG, YAN CAO HONG, BING LI WEI, ZHONG YU HAI: "Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 12, no. 5, 1 November 2015 (2015-11-01), GR, pages 6445 - 6450, XP055801062, ISSN: 1791-2997, DOI: 10.3892/mmr.2015.4326
KRAUSE MECHTHILD; DUBROVSKA ANNA; LINGE ANNETT; BAUMANN MICHAEL: "Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM , NL, vol. 109, 12 February 2016 (2016-02-12), Amsterdam , NL, pages 63 - 73, XP029914271, ISSN: 0169-409X, DOI: 10.1016/j.addr.2016.02.002
TOMOHIKO SAKABE, JUNYA AZUMI , YOSHIHISA UMEKITA, KAN TORIGUCHI , ETSURO HATANO, YASUAKI HIROOKA, GOSHI SHIOTA: "Expression of Cancer Stem Cell-associated DKK1 mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 37, no. 9, 6 September 2017 (2017-09-06), GR, pages 4881 - 4888, XP055801064, ISSN: 0250-7005, DOI: 10.21873/anticanres.11897
HONG XIAO CHUN, FEN YUAN JIAN, YAN GUO CHUN, HONG HONG, YAN CAO HONG, BING LI WEI, ZHONG YU HAI: "Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 12, no. 5, 1 November 2015 (2015-11-01), GR, pages 6445 - 6450, XP055801062, ISSN: 1791-2997, DOI: 10.3892/mmr.2015.4326
KRAUSE MECHTHILD; DUBROVSKA ANNA; LINGE ANNETT; BAUMANN MICHAEL: "Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM , NL, vol. 109, 12 February 2016 (2016-02-12), Amsterdam , NL, pages 63 - 73, XP029914271, ISSN: 0169-409X, DOI: 10.1016/j.addr.2016.02.002
TOMOHIKO SAKABE, JUNYA AZUMI , YOSHIHISA UMEKITA, KAN TORIGUCHI , ETSURO HATANO, YASUAKI HIROOKA, GOSHI SHIOTA: "Expression of Cancer Stem Cell-associated DKK1 mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 37, no. 9, 6 September 2017 (2017-09-06), GR, pages 4881 - 4888, XP055801064, ISSN: 0250-7005, DOI: 10.21873/anticanres.11897
Attorney, Agent or Firm:
BAE, KIM & LEE IP (KR)
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