Title:
COMPOSITION COMPRISING PATIENT'S JOINT FLUID-DERIVED MESENCHYMAL STEM CELL FOR TREATMENT OF RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2021/080037
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising mesenchymal stem cells derived from joint fluids of a subject suffering from rheumatoid arthritis for treatment or prevention of rheumatoid arthritis. Particularly, the composition comprising mesenchymal stem cells derived from the joint fluid of a subject in an early phase of arthritis has an excellent therapeutic or prophylactic effect on arthritis. In addition, the composition of the present invention exhibits a better therapeutic effect on arthritis when administered to a subject in an early phase of arthritis than in a late phase of arthritis.
Inventors:
LEE SANG IL (KR)
Application Number:
PCT/KR2019/014032
Publication Date:
April 29, 2021
Filing Date:
October 24, 2019
Export Citation:
Assignee:
GYEONGSANG NATIONAL UNIV HOSPITAL (KR)
International Classes:
A61K35/28; A61P19/02; A61P29/00
Foreign References:
| KR20190013465A | 2019-02-11 | |||
| US20180214489A1 | 2018-08-02 |
Other References:
LUQUE-CAMPOS NOYMAR, CONTRERAS-LÓPEZ RAFAEL A., JOSE PAREDES-MARTÍNEZ MARÍA, TORRES MARIA JOSE, BAHRAOUI SARAH, WEI MINGXING, ESPI: "Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response", FRONTIERS IN IMMUNOLOGY, vol. 10, 798, 16 April 2019 (2019-04-16), pages 1 - 11, XP055820531
CHANG WOOCHUL, PARK SANG IN, JUN SUN-YOUNG, LEE EUI-JIN, HAM HYUN-JOO, BAE YOONJIN, KIM RAN, PARK MOON-SEO, CHUNG YONG-AN, IM NOAH: "Therapeutic potential of autologous mesenchymal stem cells derived from synovial fluid in patients with degenerative arthritis", ANIMAL CELLS AND SYSTEMS, vol. 17, no. 5, 2013, pages 315 - 324, XP055820533
KIM, H. S.: "Mesenchymal Stem Cellsvs vs. Mesenchymal Stem Ceil Secretome for Rheumatoid Arthritis Treatment", JSM ARTHRITIS, vol. 1, no. 1, 4 May 2016 (2016-05-04), pages 1001, XP055578543
CHANG WOOCHUL, PARK SANG IN, JUN SUN-YOUNG, LEE EUI-JIN, HAM HYUN-JOO, BAE YOONJIN, KIM RAN, PARK MOON-SEO, CHUNG YONG-AN, IM NOAH: "Therapeutic potential of autologous mesenchymal stem cells derived from synovial fluid in patients with degenerative arthritis", ANIMAL CELLS AND SYSTEMS, vol. 17, no. 5, 2013, pages 315 - 324, XP055820533
KIM, H. S.: "Mesenchymal Stem Cellsvs vs. Mesenchymal Stem Ceil Secretome for Rheumatoid Arthritis Treatment", JSM ARTHRITIS, vol. 1, no. 1, 4 May 2016 (2016-05-04), pages 1001, XP055578543
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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