Title:
COMPOSITION COMPRISING PI3 KINASE INHIBITOR AND BCL-2 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/112381
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the prevention or treatment of a lymphoma comprising a PI3 kinase inhibitor and a B-cell lymphoma 2 (Bcl-2) inhibitor, a method for treating lymphoma by using the composition, and a use of the composition in the preparation of a medicament for the treatment of lymphoma. The PI3 kinase inhibitor according to the present invention is a compound represented by formula (1), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof. The composition exhibits excellent effects on the prevention and treatment of lymphoma due to a synergistic effect of the combination PI3 kinase inhibitor and the Bcl-2 inhibitor.
Inventors:
KIM NAM-HOON (KR)
WANG JIN SANG (KR)
KIM BAEK KYUNG (KR)
JEON BYEONGWOOK (KR)
LEE BO RAM (KR)
SON MI KWON (KR)
CHOI YEON SEO (KR)
WANG JIN SANG (KR)
KIM BAEK KYUNG (KR)
JEON BYEONGWOOK (KR)
LEE BO RAM (KR)
SON MI KWON (KR)
CHOI YEON SEO (KR)
Application Number:
PCT/KR2018/015549
Publication Date:
June 13, 2019
Filing Date:
December 07, 2018
Export Citation:
Assignee:
BORYUNG PHARM (KR)
International Classes:
C07D471/04; A61K31/4725; A61K31/519
Domestic Patent References:
| WO2016204429A1 | 2016-12-22 | |||
| WO2017205843A1 | 2017-11-30 |
Foreign References:
| US20150320755A1 | 2015-11-12 | |||
| US20170231986A1 | 2017-08-17 | |||
| US20160317541A1 | 2016-11-03 | |||
| KR20150036738A | 2015-04-07 |
Attorney, Agent or Firm:
AHN, So Young (KR)
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