Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
COMPOSITION, COMPRISING SALVIA MILTIORRHIZA BUNGE EXTRACT AS ACTIVE INGREDIENT, FOR PREVENTION OR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA OR ALOPECIA
Document Type and Number:
WIPO Patent Application WO/2021/086120
Kind Code:
A1
Abstract:
The present invention relates to a composition, comprising a Salvia miltiorrhiza Bunge extract as an active ingredient, for treatment or prevention of benign prostatic hyperplasia or alopecia. The Salvia miltiorrhiza Bunge extract comprises 2-70 % of tanshinones including tanshinone1, tanshinone2a, cryptotanshinone, and dihydrotanshinone and can be used to provide a pharmaceutical composition and a health functional food for treatment and prevention of alopecia and benign prostatic hyperplasia.

Inventors:
YOON JOO SEOG (KR)
SEO KANG SIK (KR)
HAN JEONG SU (KR)
KIM EUN KYUNG (KR)
Application Number:
PCT/KR2020/015058
Publication Date:
May 06, 2021
Filing Date:
October 30, 2020
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
CUROME BIOSCIENCES CO LTD (KR)
International Classes:
A61K36/537; A23L33/105; A23L33/16; A61K31/343; A61K33/30; A61P13/08; A61P17/14
Foreign References:
KR100818586B12008-04-01
KR20180055945A2018-05-28
KR20190049467A2019-05-09
KR20120053248A2012-05-25
US5234698A1993-08-10
KR20120020639A2012-03-08
KR20010076810A2001-08-16
KR100259037B12000-07-01
Other References:
WANG CHAO; DU XIAOLING; YANG RUI; LIU JIE; XU DA; SHI JIANDANG; CHEN LINFENG; SHAO RUI; FAN GUANWEI; GAO XIUMEI; TIAN GUO; ZHU YAN: "The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats", JOURNAL OF STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD., OXFORD., GB, vol. 145, 5 October 2014 (2014-10-05), GB, pages 28 - 37, XP029112266, ISSN: 0960-0760, DOI: 10.1016/j.jsbmb.2014.09.026
BERRY, S.J.COFFEY, D.S.WALSH, P.C.EWING, L.L.: "The development of human benign prostatic hyperplasia with age", J. UROL., vol. 132, 1984, pages 474 - 479
SARMA, A.V.WEI, J.T.: "Clinical practice. Benign prostatic hyperplasia and lower urinary tract symptoms", N. ENGL. J. MED., vol. 367, 2012, pages 248 - 257
KIM, S.K.SEOK, H.PARK, H.J.JEON, H.S.KANG, S.W.LEE, B.C.YI, J.SONG, S.Y.LEE, S.H.KIM, Y.O. ET AL.: "Inhibitory effect of curcumin on testosterone induced benign prostatic hyperplasia rat model. BMC Complement", ALTERN. MED., vol. 15, 2015, pages 380 - 386
CHOI, H.M.JUNG, Y.PARK, J.B.KIM, H.L.YOUN, D.H.KANG, J.W.JEONG, M.Y.LEE, J.H.YANG, W.M.LEE, S.G. ET AL.: "Cinnamomi cortex (Cinnamomum verum) suppresses testosterone-induced benign prostatic hyperplasia by regulating 5a-reductase", SCI. REP., vol. 6, 2016, pages 31906 - 31917
CHEN, Y.ROBLES, A.I.MARTINEZ, L.A.LIU, F.GIMENEZ-CONTI, I.B.CONTI, C.J.: "Expression of Gl cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors in androgen-induced prostate proliferation in castrated rats", CELL GROWTH DIFFER, vol. 7, 1996, pages 1571 - 1578
WANG, W.BERGH, A.DAMBER, J.E.: "Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epithelium", PROSTATE, vol. 61, 2004, pages 60 - 72
CARDILLO, M.BERCHEM, G.TARKINGTON, M.A.KRAJEWSKI, S.KRAJEWSKI, M.REED, J.C.TEHAN, T.ORTEGA, L.LAGE, J.GELMANN, E.P.: "Resistance to apoptosis and up regulation of Bcl-2 in benign prostatic hyperplasia after androgen deprivation", J. UROL., vol. 158, 1997, pages 212 - 216, XP005568088, DOI: 10.1097/00005392-199707000-00073
DENNIS A. HOLTMARK A. LEVYHYE JA OHJILL M. ERBJULIE I.HEASLIPMARTIN BRANDTHSUAN YIN LAN-HARGESTBRIAN W. METCALF: "Inhibition of steroid 5.alpha.-reductase by unsaturated 3-carboxy steroids", J. MED. CHEM., vol. 333, 1990, pages 943 - 950
PARK, E.S.LEE, M.Y.JEON, W.W.SEO, C.S.YOU, S.S.SHIN, H.K.: "Paljung-San, a traditional herbal medicine, attenuates benign prostatic hyperplasia in vitro and in vivo", J. ETHNOPHARMACOL., vol. 218, 2018, pages 109 - 115
MARKS, L.S.PARTIN, A.W.EPSTEIN, J.I.TYLER, V.E.SIMON, I.MACAIRAN, M.L.CHAN, T.L.DOREY, F.J.GARRIS, J.B.VELTRI, R.W. ET AL.: "Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia", J. UROL., vol. 163, 2000, pages 1451 - 1456, XP005555426, DOI: 10.1016/S0022-5347(05)67641-0
SHAN GAOSHIQIN LIQIN LIFUYONG ZHANGMENGQI SUNZILIN WANSHURONG WANG: "Protective effects of salvianolic acid B against hydrogen peroxide-induced apoptosis of human umbilical vein endothelial cells and underlying mechanisms", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 44, 2019, pages 457 - 468
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
Download PDF: