Title:
COMPOSITION, COMPRISING SEA CUCUMBER-DERIVED SAPONIN COMPOUND, FOR PREVENTING, ALLEVIATING, OR TREATING NEUROPATHY
Document Type and Number:
WIPO Patent Application WO/2021/187679
Kind Code:
A1
Abstract:
The present invention relates to a composition, comprising a sea cucumber-derived saponin compound, for preventing, alleviating, or treating neuropathy. More specifically, the sea cucumber-derived saponin compound of the present invention decreases the function of TRPA1 protein that mediates the transmission of a pain signal through the migration of calcium ions and, as such, can be advantageously used as an active ingredient for a medicine, a food, etc. for preventing, alleviating, or treating neuropathy.
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Inventors:
LEE YEON JU (KR)
CHOI HAN SOL (KR)
LEE HYI SEUNG (KR)
HYUN JUNG MI (KR)
YANG JEUNG EUN (KR)
SONG MYUNG JIN (KR)
CHOI HAN SOL (KR)
LEE HYI SEUNG (KR)
HYUN JUNG MI (KR)
YANG JEUNG EUN (KR)
SONG MYUNG JIN (KR)
Application Number:
PCT/KR2020/009363
Publication Date:
September 23, 2021
Filing Date:
July 16, 2020
Export Citation:
Assignee:
KOREA INST OCEAN SCI & TECH (KR)
International Classes:
A61K31/7048; A23L33/10; A61K35/616; A61P25/00; C07H17/04
Foreign References:
| US20090269415A1 | 2009-10-29 | |||
| KR20130104930A | 2013-09-25 |
Other References:
ZHAO YING-CAI, XUE CHANG-HU, ZHANG TIAN-TIAN, WANG YU-MING: "Saponins from Sea Cucumber and Their Biological Activities", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 66, no. 28, 18 July 2018 (2018-07-18), US, pages 7222 - 7237, XP055852214, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.8b01770
KITAGAWA I, ET AL.: "STRUCTURES OF FOUR NEW TRITERPENOIDAL OLIGOGLYCOSIDES, BIVITTOSIDE A, B, C, AND D, FROM THE SEA CUCUMBER BOHADSCHIA BIVITTATA MITSUKURI", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 29, no. 01, 1 January 1981 (1981-01-01), JP, pages 282 - 285, XP001182694, ISSN: 0009-2363
CHOI HANSOL, OH CHULHONG, HYUN JEONGMI, YANG JEUNGEUN, SONG MYUNG JIN, LEE HYI-SEUNG, LEE YEON-JU: "Triterpene Glycosides Isolated from the Edible Sea Cucumber Bohadschia vitiensis and Their Antagonistic Activity against Transient Receptor Potential Ankyrin 1", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 68, no. 19, 13 May 2020 (2020-05-13), US, pages 5349 - 5355, XP055852221, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.0c00847
KITAGAWA I, ET AL.: "STRUCTURES OF FOUR NEW TRITERPENOIDAL OLIGOGLYCOSIDES, BIVITTOSIDE A, B, C, AND D, FROM THE SEA CUCUMBER BOHADSCHIA BIVITTATA MITSUKURI", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 29, no. 01, 1 January 1981 (1981-01-01), JP, pages 282 - 285, XP001182694, ISSN: 0009-2363
CHOI HANSOL, OH CHULHONG, HYUN JEONGMI, YANG JEUNGEUN, SONG MYUNG JIN, LEE HYI-SEUNG, LEE YEON-JU: "Triterpene Glycosides Isolated from the Edible Sea Cucumber Bohadschia vitiensis and Their Antagonistic Activity against Transient Receptor Potential Ankyrin 1", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 68, no. 19, 13 May 2020 (2020-05-13), US, pages 5349 - 5355, XP055852221, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.0c00847
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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