Title:
COMPOSITION CONTAINING SODIUM PYRUVATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/115156
Kind Code:
A1
Abstract:
Disclosed are a composition containing sodium pyruvate for oral administration and the use thereof, wherein the composition comprises the following essential components: (a) 2.0-25.0 parts by weight of sodium pyruvate; and (b) 5.0-100.0 parts by weight of anhydrous glucose or other carbohydrates. The above-mentioned composition can be used to treat diabetes and organ complications thereof, or can be used to treat conditions involving increased pyruvate dehydrogenase (PDH) activity.
Inventors:
ZHOU FANGQIANG (CN)
Application Number:
PCT/CN2020/133041
Publication Date:
June 17, 2021
Filing Date:
December 01, 2020
Export Citation:
Assignee:
ZHOU FANGQIANG (CN)
International Classes:
A23L33/125; A23L33/10; A61K31/19; A61P3/08; A61P3/10
Foreign References:
| CN110859307A | 2020-03-06 | |||
| CN103316038A | 2013-09-25 | |||
| CN103263383A | 2013-08-28 | |||
| CN103316038A | 2013-09-25 | |||
| CN101164530A | 2008-04-23 | |||
| CN103385868A | 2013-11-13 |
Other References:
BAO XIAO-DONG, LIU WEI-WEI; ZHOU FANG-QIANG; HU SEN: "Effects of Pyruvate-Oral Rehydration Solution on Lactate Level and Plasma Volume During Oral Resuscitation in Dogs with 50% TBSA Full Thickness Burn Injury", JOURNAL OF TRAUMATIC SURGERY, vol. 19, no. 1, 1 January 2017 (2017-01-01), pages 30 - 34, XP055820279, DOI: 10.3969/j.issn.1009-4237.2017.01.008
WEIPING BAI, JUAN LI, ＲUILI HAN, YING GU, XUDE SUN, JING YE, FANGQIANG ZHOU, CHANGJUN GAO: "Effects of Hypotonic Pyruvate Oral Rehydration Solution on Brain Injury in Rats Subjected to Asphyxial Cardiac Arrest", CHINESE JOURNAL OF INJURY REPAIR AND WOUND HEALING(ELECTRONIC EDITION, vol. 12, no. 5, 1 October 2017 (2017-10-01), pages 326 - 330, XP055820275, DOI: 10.3877/cma.j.issn.1673-9450.2017.05.002
FANGQIANG ZHOU, LIU RUI: "Potential Applications of Pyruvate in Fluid Therapy of Critical Illness", CHINESE JOURNAL OF INJURY REPAIR AND WOUND HEALING(ELECTRONIC EDITION, vol. 12, no. 5, 1 October 2017 (2017-10-01), pages 321 - 325, XP055820265, DOI: 10.3877/cma.j.issn.1673-9450.2017.05.001
FU JUNDA, WANG YUQING, QI YANXIU: "Protective Effects of Different Doses of Sodium Pyruvate on the Retina of Diabetic Rats", JOURNAL OF CLINICAL MEDICAL LITERATURE, vol. 2, no. 11, 1 April 2015 (2015-04-01), pages 2044 - 2045, XP055820261, DOI: 10.16281/j.cnki.jocml.2015.11.022
WEIPING BAI, JUAN LI, ＲUILI HAN, YING GU, XUDE SUN, JING YE, FANGQIANG ZHOU, CHANGJUN GAO: "Effects of Hypotonic Pyruvate Oral Rehydration Solution on Brain Injury in Rats Subjected to Asphyxial Cardiac Arrest", CHINESE JOURNAL OF INJURY REPAIR AND WOUND HEALING(ELECTRONIC EDITION, vol. 12, no. 5, 1 October 2017 (2017-10-01), pages 326 - 330, XP055820275, DOI: 10.3877/cma.j.issn.1673-9450.2017.05.002
FANGQIANG ZHOU, LIU RUI: "Potential Applications of Pyruvate in Fluid Therapy of Critical Illness", CHINESE JOURNAL OF INJURY REPAIR AND WOUND HEALING(ELECTRONIC EDITION, vol. 12, no. 5, 1 October 2017 (2017-10-01), pages 321 - 325, XP055820265, DOI: 10.3877/cma.j.issn.1673-9450.2017.05.001
FU JUNDA, WANG YUQING, QI YANXIU: "Protective Effects of Different Doses of Sodium Pyruvate on the Retina of Diabetic Rats", JOURNAL OF CLINICAL MEDICAL LITERATURE, vol. 2, no. 11, 1 April 2015 (2015-04-01), pages 2044 - 2045, XP055820261, DOI: 10.16281/j.cnki.jocml.2015.11.022
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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