Title:
COMPOSITION CONTAINING TETRACYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2012/023597
Kind Code:
A1
Abstract:
A composition comprising a substance represented by general formula (I), a pharmaceutically acceptable carrier and a dissolution aid is useful for the improvement in the solubility, oral absorbability and/or absorbability in blood of the poorly-water-soluble or water-insoluble tetracyclic compound that is useful as a prophylactic and/or therapeutic agent for cancer, depression and cognitive dysfunction and has an ALK inhibitory activity. [In the formula, the symbols are as defined in the description.]
Inventors:
FURUMOTO KENTARO (JP)
SHIRAKI KOJI (JP)
HIRAYAMA TOMOAKI (JP)
SHIRAKI KOJI (JP)
HIRAYAMA TOMOAKI (JP)
Application Number:
PCT/JP2011/068735
Publication Date:
February 23, 2012
Filing Date:
August 19, 2011
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
FURUMOTO KENTARO (JP)
SHIRAKI KOJI (JP)
HIRAYAMA TOMOAKI (JP)
FURUMOTO KENTARO (JP)
SHIRAKI KOJI (JP)
HIRAYAMA TOMOAKI (JP)
International Classes:
A61K31/403; A61K31/343; A61K31/381; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/5377; A61K47/10; A61K47/14; A61K47/20; A61K47/22; A61K47/34; A61P25/24; A61P25/28; A61P35/00; A61P35/02; A61P35/04; A61P43/00
Domestic Patent References:
| WO2008051547A1 | 2008-05-02 | |||
| WO2009073620A2 | 2009-06-11 | |||
| WO2002043704A1 | 2002-06-06 | |||
| WO2010143664A1 | 2010-12-16 |
Foreign References:
| JPH0892090A | 1996-04-09 | |||
| JP2009100783A | 2009-05-14 | |||
| JP2008280352A | 2008-11-20 |
Other References:
GARBETT, N.C. ET AL.: "Extending nature's leads: the anticancer agent ellipticine", CURR MED CHEM ANTICANCER AGENTS, vol. 4, no. 2, 2004, pages 149 - 172
NATURE, vol. 448, 2007, pages 561 - 566
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 685 - 700
CURRENT MEDICINAL CHEMISTRY: ANTI-CANCER AGENTS, vol. 4, no. 2, 2004, pages 149 - 172
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 23, 1993, pages 10628 - 36
ORGANIC LETTERS, vol. 9, no. 24, 2007, pages 5027 - 5029
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, no. 2, 1991, pages 321 - 3
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 24, 2008, pages 6479 - 6481
ORGANIC LETTERS, vol. 8, no. 3, 2006, pages 367 - 370
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 13, 2008, pages 3814 - 3824
R. TAKANO ET AL., PHARM. RES., vol. 23, 2006, pages 1144 - 1156
See also references of EP 2606886A4
NATURE, vol. 448, 2007, pages 561 - 566
NEUROPSYCHOPHARMACOLOGY, vol. 33, 2008, pages 685 - 700
CURRENT MEDICINAL CHEMISTRY: ANTI-CANCER AGENTS, vol. 4, no. 2, 2004, pages 149 - 172
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 23, 1993, pages 10628 - 36
ORGANIC LETTERS, vol. 9, no. 24, 2007, pages 5027 - 5029
JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 28, no. 2, 1991, pages 321 - 3
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 24, 2008, pages 6479 - 6481
ORGANIC LETTERS, vol. 8, no. 3, 2006, pages 367 - 370
JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 13, 2008, pages 3814 - 3824
R. TAKANO ET AL., PHARM. RES., vol. 23, 2006, pages 1144 - 1156
See also references of EP 2606886A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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Claims: