Title:
COMPOSITION FOR ELONGATING TELOMERES
Document Type and Number:
WIPO Patent Application WO/2021/054373
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a new use for a papaya fermented food product. A composition according to the present invention contains a papaya fermented food product as an active ingredient, and is used for elongating telomeres.
Inventors:
HAYASHI YUKIYASU (JP)
FAIS STEFANO (IT)
FAIS STEFANO (IT)
Application Number:
PCT/JP2020/035121
Publication Date:
March 25, 2021
Filing Date:
September 16, 2020
Export Citation:
Assignee:
OSATO INT INC (JP)
International Classes:
A61K36/185; A23L33/10; A61K35/741; A61P43/00
Domestic Patent References:
| WO2016093104A1 | 2016-06-16 | |||
| WO2016027334A1 | 2016-02-25 | |||
| WO2016027333A1 | 2016-02-25 |
Foreign References:
| JP2006075086A | 2006-03-23 | |||
| JP2011041478A | 2011-03-03 |
Other References:
MARIANTONIA LOGOZZI, DAVIDE MIZZONI , ROSSELLA DI RAIMO , DANIELE MACCHIA , MASSIMO SPADA AND STEFANO FAIS: "Oral Administration of Fermented Papaya (FPP(R)) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response.", CANCERS, vol. 11, no. 1, 118, January 2019 (2019-01-01), pages 1 - 19, XP055807551, DOI: 10.3390/cancers11010118 >
LIN LIU, JAMES R. TRIMARCHI, PAULA NAVARRO, MARIA A. BLASCO, AND DAVID L. KEEF: "Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis", J. BIOL. CHEM., vol. 278, no. 34, 2003, pages 31998 - 32004, XP055807553
ISHIKAWA, FUYUKI: "Cellular Senescence and Chromosome Telomeres", JAPANESE JOURNAL OF GERIATRICS, vol. 37, no. 1, 25 January 2000 (2000-01-25), JP , pages 19 - 25, XP009535397, ISSN: 0300-9173, DOI: 10.3143/geriatrics.37.19
LOGOZZI MARIANTONIA, ROSSELLA DI, RAIMO DAVIDE, MIZZONI STEFANO, FAIS: "Anti-aging and anti-tumor effect of FPP(R) supplementation", EUR. J. TRANSL. MYOL., vol. 30, no. 1, April 2020 (2020-04-01), pages 58 - 61, XP055807578
MARIANTONIA LOGOZZI , ROSSELLA DI RAIMO , DAVIDE MIZZONI , MAURO ANDREOTTI , MASSIMO SPADA , DANIELE MACCHIA AND STEFANO FAI: "Beneficial Effects of Fermented Papaya Preparation (FPP®) Supplementation on Redox Balance and Aging in a Mouse Model", ANTIOXIDANTS, vol. 9, no. 2, February 2020 (2020-02-01), pages 144, XP055807588, DOI: 10.3390/antiox9020144 >
ARUOMA O.I. ET AL.: "Applications and bioefficacy of the functional food supplement fermented papaya preparation", TOXICOLOGY, vol. 278, 2010, pages 6 - 16, XP027484853, DOI: 10.1016/j.tox.2010.09.006
ARUOMA O.I. ET AL.: "Diabetes as a risk factor to cancer: Functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer", MUTAT. RES./FUNDAM. MOL. MECH. MUTAGEN., vol. 768, 2014, pages 60 - 68
LOGOZZI M ET AL.: "Oral Administration of Fermented Papaya (FPP) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response", CANCERS (BASEL, vol. 11, no. 1, 20 January 2019 (2019-01-20), XP055807551
See also references of EP 4032537A4
LIN LIU, JAMES R. TRIMARCHI, PAULA NAVARRO, MARIA A. BLASCO, AND DAVID L. KEEF: "Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis", J. BIOL. CHEM., vol. 278, no. 34, 2003, pages 31998 - 32004, XP055807553
ISHIKAWA, FUYUKI: "Cellular Senescence and Chromosome Telomeres", JAPANESE JOURNAL OF GERIATRICS, vol. 37, no. 1, 25 January 2000 (2000-01-25), JP , pages 19 - 25, XP009535397, ISSN: 0300-9173, DOI: 10.3143/geriatrics.37.19
LOGOZZI MARIANTONIA, ROSSELLA DI, RAIMO DAVIDE, MIZZONI STEFANO, FAIS: "Anti-aging and anti-tumor effect of FPP(R) supplementation", EUR. J. TRANSL. MYOL., vol. 30, no. 1, April 2020 (2020-04-01), pages 58 - 61, XP055807578
MARIANTONIA LOGOZZI , ROSSELLA DI RAIMO , DAVIDE MIZZONI , MAURO ANDREOTTI , MASSIMO SPADA , DANIELE MACCHIA AND STEFANO FAI: "Beneficial Effects of Fermented Papaya Preparation (FPP®) Supplementation on Redox Balance and Aging in a Mouse Model", ANTIOXIDANTS, vol. 9, no. 2, February 2020 (2020-02-01), pages 144, XP055807588, DOI: 10.3390/antiox9020144 >
ARUOMA O.I. ET AL.: "Applications and bioefficacy of the functional food supplement fermented papaya preparation", TOXICOLOGY, vol. 278, 2010, pages 6 - 16, XP027484853, DOI: 10.1016/j.tox.2010.09.006
ARUOMA O.I. ET AL.: "Diabetes as a risk factor to cancer: Functional role of fermented papaya preparation as phytonutraceutical adjunct in the treatment of diabetes and cancer", MUTAT. RES./FUNDAM. MOL. MECH. MUTAGEN., vol. 768, 2014, pages 60 - 68
LOGOZZI M ET AL.: "Oral Administration of Fermented Papaya (FPP) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response", CANCERS (BASEL, vol. 11, no. 1, 20 January 2019 (2019-01-20), XP055807551
See also references of EP 4032537A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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