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Title:
COMPOSITION FOR FORMING HYDROGEL, HYDROGEL, AND METHOD FOR PRODUCING COMPOSITION FOR FORMING HYDROGEL
Document Type and Number:
WIPO Patent Application WO/2020/153382
Kind Code:
A1
Abstract:
Provided is a composition for forming a hydrogel that makes it possible to form a sterilized hydrogel having high mechanical strength. Also provided are a hydrogel in which the composition for forming a hydrogel is used and a method for producing the composition for forming a hydrogel. The composition for forming a hydrogel is characterized in that said composition for forming a hydrogel contains a vinyl alcohol polymer having an ethylenically unsaturated group and a polymerization degree of 450 or more, the introduction rate of the ethylenically unsaturated group is 0.01-10 mol% in all structural units constituting the vinyl alcohol polymer, and no microorganisms detectable by the sterility test method specified in the general test methods of the Japanese Pharmacopoeia are present.

Inventors:
FUJITA AKIO (JP)
KOBAYASHI GORO (JP)
Application Number:
PCT/JP2020/002007
Publication Date:
July 30, 2020
Filing Date:
January 21, 2020
Export Citation:
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Assignee:
KURARAY CO (JP)
International Classes:
C08F8/00; C08F16/06; C08F299/00; C08G75/04
Domestic Patent References:
WO2017010459A12017-01-19
Foreign References:
JPH10513408A1998-12-22
JPH047302A1992-01-10
JPH04222892A1992-08-12
JPH08206188A1996-08-13
JPH10513408A1998-12-22
JP2011008213A2011-01-13
JP2002506813A2002-03-05
JP2008510021A2008-04-03
JP2007246770A2007-09-27
JP2015004059A2015-01-08
Other References:
BRYANT STEPHANIE J., DAVIS-AREHART KELLY A., LUO NING, SHOEMAKER RICHARD K., ARTHUR JEFFREY A., ANSETH KRISTI S.: "Synthesis and Characterization of Photopolymerized Multifunctional Hydrogels:  Water-Soluble Poly(Vinyl Alcohol) and Chondroitin Sulfate Macromers for Chondrocyte Encapsulation", MACROMOLECULES, vol. 37, no. 18, 8 July 2004 (2004-07-08), Washington DC United States, pages 6726 - 6733, XP009529085, ISSN: 0024-9297, DOI: 10.1021/ma0499324
CTA BIOMATERIALIA, vol. 6, 2010, pages 3899 - 3907
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, vol. 75, 2000, pages 541 - 546
"Polymer Chemistry", JOURNAL OF POLYMER SCIENCE, vol. 35, 1997, pages 3603 - 3611
BIOMATERIALS, vol. 23, 2002, pages 4325 - 4332
MACROMOLECULES, vol. 37, 2004, pages 6726 - 6733
"Cell Culture Technology", 1999, ASAKURA PUBLISHING CO.
SHIGERU KIMURA: "Insect Biological Factory", 2000, KOGYO CHOSAKAI PUBLISHING CO., LTD.
See also references of EP 3916024A4
Attorney, Agent or Firm:
OHTANI PATENT OFFICE (JP)
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