Title:
COMPOSITION FOR IMPROVING AND TREATING LIVER-RELATED DISEASES, COMPRISING P-COUMARIC ACID AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/128121
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition for improving and treating obesity or liver-related diseases, comprising p-Coumaric acid as an active ingredient. In order to confirm that p-Coumaric acid (PCA) treats liver inflammation or liver fibrosis, a mouse model that was fed a high fat and high sucrose (HFHS) diet was treated with the p-Coumaric acid of the present invention. As a result, confirmed were the effects of: (1) reducing total cholesterol and suppressing accumulation of free cholesterol, and increasing glucose tolerance and insulin sensitivity; (2) suppressing liver tissue inflammatory genes and proteins; and (3) inhibiting fibrosis-related genes or proteins. In addition, the role of p-Coumaric acid (PCA) in down-regulating NLRP3 activation and caspase-1 cleavage was first identified, and thus, p-Coumaric acid (PCA) is effective in treating liver fibrosis and liver inflammation and can be helpfully used in related projects.
Inventors:
KANG INHAE (KR)
TIEN THI MY TRUONG (KR)
SEO SEOK HEE (KR)
TIEN THI MY TRUONG (KR)
SEO SEOK HEE (KR)
Application Number:
PCT/KR2022/012597
Publication Date:
July 06, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
JEJU NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K31/192; A23L33/10; A61P1/16; A61P43/00
Foreign References:
| KR20140041632A | 2014-04-04 | |||
| KR20150088223A | 2015-07-31 |
Other References:
YOON DAE SEONG; CHO SU YEON; YOON HYE JIN; KIM SANG RYONG; JUNG UN JU: "Protective effects of p-coumaric acid against high-fat diet-induced metabolic dysregulation in mice", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 142, 29 July 2021 (2021-07-29), FR , XP086785742, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2021.111969
PARVIZI FARKHONDEH, YAGHMAEI PARICHEHREH, ALI SEYED, ROHANI HAERI, ALI MARD SEYED: "Hepatoprotective properties of p-coumaric acid in a rat model of ischemiareperfusion", AVICENNA JOURNAL OF PHYTOMEDICINE, vol. 10, no. 6, 1 November 2020 (2020-11-01), pages 633 - 640, XP093075906
CHA HANVIT; LEE SEOYOON; LEE JIN HYUP; PARK JEEN-WOO: "Protective effects ofp-coumaric acid against acetaminophen-induced hepatotoxicity in mice", FOOD AND CHEMICAL TOXICOLOGY, PERGAMON, GB, vol. 121, 24 August 2018 (2018-08-24), GB , pages 131 - 139, XP085506167, ISSN: 0278-6915, DOI: 10.1016/j.fct.2018.08.060
TRUONG, T. M. T. ET AL.: "p-Coumaric supplementation prevents high fat and high sucrose-mediated hepatic inflammation and fiborosis", 2021 INTERNATIONAL SYMPOSIUM AND ANNUAL MEETING OF THE KSABC, 24 August 2021 (2021-08-24), pages 46
TRUONG THI MY TIEN: "p-Coumaric acid prevents high fat and high surcrose-mediated hepatic inflammation and fibrosis", THESIS GRADUATE SCHOOL JEJU NATIONAL UNIVERSITY, 1 February 2022 (2022-02-01), pages 1 - 55, XP093075908
PARVIZI FARKHONDEH, YAGHMAEI PARICHEHREH, ALI SEYED, ROHANI HAERI, ALI MARD SEYED: "Hepatoprotective properties of p-coumaric acid in a rat model of ischemiareperfusion", AVICENNA JOURNAL OF PHYTOMEDICINE, vol. 10, no. 6, 1 November 2020 (2020-11-01), pages 633 - 640, XP093075906
CHA HANVIT; LEE SEOYOON; LEE JIN HYUP; PARK JEEN-WOO: "Protective effects ofp-coumaric acid against acetaminophen-induced hepatotoxicity in mice", FOOD AND CHEMICAL TOXICOLOGY, PERGAMON, GB, vol. 121, 24 August 2018 (2018-08-24), GB , pages 131 - 139, XP085506167, ISSN: 0278-6915, DOI: 10.1016/j.fct.2018.08.060
TRUONG, T. M. T. ET AL.: "p-Coumaric supplementation prevents high fat and high sucrose-mediated hepatic inflammation and fiborosis", 2021 INTERNATIONAL SYMPOSIUM AND ANNUAL MEETING OF THE KSABC, 24 August 2021 (2021-08-24), pages 46
TRUONG THI MY TIEN: "p-Coumaric acid prevents high fat and high surcrose-mediated hepatic inflammation and fibrosis", THESIS GRADUATE SCHOOL JEJU NATIONAL UNIVERSITY, 1 February 2022 (2022-02-01), pages 1 - 55, XP093075908
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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