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Title:
COMPOSITION INCLUDING LACTOBACILLUS PARACASEI-DERIVED VESICLES FOR PREVENTING, TREATING, OR ALLEVIATING VIRAL INFECTIOUS DISEASES OR RESPIRATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/164012
Kind Code:
A1
Abstract:
The present invention relates to a composition including Lactobacillus paracasei-derived vesicles as an active ingredient for preventing, alleviating, or treating viral infectious diseases or respiratory diseases. The present inventors have confirmed that when vesicles are isolated from Lactobacillus paracasei bacteria and administered orally, the vesicles are delivered to the lungs, and the occurrence of respiratory diseases is significantly inhibited when the vesicles are administered to an animal model for respiratory diseases caused by chemical, viral, and bacterial causative factors. In addition, it was confirmed that when Lactobacillus paracasei-derived vesicles are administered to a COVID-19 virus or influenza virus infection model, replication of the COVID-19 virus is remarkably inhibited, the occurrence of pneumonia is significantly inhibited, and clinical symptoms caused by the influenza virus are significantly inhibited. Therefore, the Lactobacillus paracasei-derived vesicles according to the present invention are expected to be useful for developing medicines or functional health foods for preventing, alleviating symptoms of, or treating viral infectious diseases or respiratory diseases.

Inventors:
KIM, Yoon-Keun (KR)
Application Number:
PCT/KR2021/018664
Publication Date:
August 04, 2022
Filing Date:
December 09, 2021
Export Citation:
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Assignee:
MD HEALTHCARE INC. (KR)
International Classes:
A61K35/747; A61P31/12; A61P31/14; A61P29/00; A23L33/135
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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