Title:
COMPOSITION FOR INHIBITING FORMATION OF SNARE COMPLEX, CONTAINING MYRICETIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2017/018847
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting the formation of a snare complex, containing myricetin derivatives, and can provide a composition for inhibiting the formation of a snare complex, in which myricetin derivatives, which have novel structures and are obtained by the acylation of myricetin, in addition to laricitrin, combretol, and syringetin, which is one of the derivatives of myricetin, are used as a SNARE targeting prodrug, since the myricetin derivatives have an activity of inhibiting the formation of a snare complex in vivo. According to research results, the myricetin derivatives are considered to exhibit an effect of being bioconverted into myricetin in a cell. The myricetin derivatives lost the dark color of conventional myricetin and properties thereof were changed such that the myricetin derivatives have properties of photostability and fat solubility. Therefore, since stable form myricetin derivatives are absorbed into a cell such that an activity, possessed by normal myricetin, of inhibiting the formation of a SNARE complex are exhibited, the present invention can exhibit an excellent function as a material usable as a SNARE targeting prodrug, and as a composition for inhibiting the formation of a snare complex, containing the same.
Inventors:
KWEON DAE HYUK (KR)
PARK JOON BUM (KR)
JUNG YOUNG HUN (KR)
CHUNG WOO JAE (KR)
HEO PA UL (KR)
PARK JOON BUM (KR)
JUNG YOUNG HUN (KR)
CHUNG WOO JAE (KR)
HEO PA UL (KR)
Application Number:
PCT/KR2016/008333
Publication Date:
February 02, 2017
Filing Date:
July 29, 2016
Export Citation:
Assignee:
UNIV SUNGKYUNKWAN RES & BUS (KR)
International Classes:
A61K31/352; A61K8/49; A61K31/353; A61Q19/00; C07D311/28
Domestic Patent References:
| WO2014012075A2 | 2014-01-16 |
Foreign References:
| KR20080083438A | 2008-09-18 | |||
| CN102875620A | 2013-01-16 |
Other References:
KAWANO, N. ET AL.: "The Partial Demethylation of Flavones. III. Preparation of Rhamnetin and 7-O-Methylmyricetin", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 15, no. 5, 1967, pages 711 - 712, XP009103478
CHO, M. H ET AL.: "Characterization of Regiospecific Flavonoid 3' /5'-O-methyltransferase from Tomato and its Application in Flavonoid Biotransformation", JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, vol. 55, no. 6, 2012, pages 749 - 755, XP055350018
DEMETZOS, C . ET AL.: "Structure Elucidation, Conformational Analysis and Thermal Effects on Membrane Bilayers of an Antimicrobial Myricetin Ether Derivative", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 38, no. 3, 2001, pages 703 - 710, XP055350022
KAIHATSU, K . ET AL.: "Potential Anti-influenza Virus Agents Based on Coffee Ingredients and Natural Flavonols", NATURAL PRODUCTS CHEMISTRY & RESEARCH, vol. 2, no. 2, 2014, pages 1000129, XP055350025
MAININI, F. ET AL.: "Synthesis, Molecular Characterization and Preliminary Antioxidant Activity Evaluation of Quercetin Fatty Esters", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 90, no. 11, 2013, pages 1751 - 1759, XP055221995
CHO, M. H ET AL.: "Characterization of Regiospecific Flavonoid 3' /5'-O-methyltransferase from Tomato and its Application in Flavonoid Biotransformation", JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, vol. 55, no. 6, 2012, pages 749 - 755, XP055350018
DEMETZOS, C . ET AL.: "Structure Elucidation, Conformational Analysis and Thermal Effects on Membrane Bilayers of an Antimicrobial Myricetin Ether Derivative", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 38, no. 3, 2001, pages 703 - 710, XP055350022
KAIHATSU, K . ET AL.: "Potential Anti-influenza Virus Agents Based on Coffee Ingredients and Natural Flavonols", NATURAL PRODUCTS CHEMISTRY & RESEARCH, vol. 2, no. 2, 2014, pages 1000129, XP055350025
MAININI, F. ET AL.: "Synthesis, Molecular Characterization and Preliminary Antioxidant Activity Evaluation of Quercetin Fatty Esters", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 90, no. 11, 2013, pages 1751 - 1759, XP055221995
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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