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Patent Searching and Data


Title:
COMPOSITION FOR INHIBITING MYELOID-DERIVED SUPPRESSOR CELL COMPRISING MITF INHIBITOR AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/033973
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting myeloid-derived suppressor cells (MDSC) comprising a microphthalmia-associated transcription factor (MITF) inhibitor as an active ingredient. Specifically, it was confirmed that an MDSC is activated in a cancer cell microenvironment to lower an immune response, and an MITF is involved in the activation of the MDSC, and the MDSC can be inhibited using the MITF inhibitor. Thus, a composition comprising the MITF inhibitor as an active ingredient can be effectively used to alleviate a decrease in immune response caused by an MDSC and to increase an efficiency of anticancer immunotherapy.

Inventors:
LIM JONG SEOK (KR)
LEE A RAM (KR)
LIM JI HYUN (KR)
LEE MYONG SOK (KR)
Application Number:
PCT/KR2020/010480
Publication Date:
February 25, 2021
Filing Date:
August 07, 2020
Export Citation:
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Assignee:
UNIV SOOKMYUNG WOMENS IND ACAD COOP FOUND (KR)
International Classes:
A61K31/4375; A61K31/353; A61K45/06; A61P35/00; A61P37/02
Other References:
WIEDEMANN GABRIELA M, AITHAL CELINA, KRAECHAN ANGELINA, HEISE CONSTANZE, CADILHA BRUNO L, ZHANG JIN, DUEWELL PETER, BALLOTTI ROBER: "Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma", TRANSLATIONAL ONCOLOGY, NEOPLASIA PRESS, UNITED STATES, vol. 12, no. 2, 1 February 2019 (2019-02-01), United States, pages 350 - 360, XP055782105, ISSN: 1936-5233, DOI: 10.1016/j.tranon.2018.10.014
INES HAMMAMI;JINGKUI CHEN;FREDERIC MURSCHEL;VINCENZO BRONTE;GREGORY DE CRESCENZO;MARIO JOLICOEUR: "Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models", BMC CELL BIOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 4 July 2012 (2012-07-04), GB, pages 18, XP021115087, ISSN: 1471-2121, DOI: 10.1186/1471-2121-13-18
SONG YOUNG CHAN; LEE YONGHEE; KIM HYEONG MI; HYUN MOO YEOL; LIM YUN YOUNG; SONG KYE YONG; KIM BEOM JOON: "Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3 beta in B16F10 melanoma cells", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 35, no. 4, 31 March 2015 (2015-03-31), GR, pages 1011 - 1016, XP009513538, ISSN: 1107-3756, DOI: 10.3892/ijmm.2015.2113
WEIDONG LI, SAUD SHAKIR M., YOUNG MATTHEW R., CHEN GUOHONG, HUA BAOJIN: "Targeting AMPK for cancer prevention and treatment", ONCOTARGET, vol. 6, no. 10, 20 March 2015 (2015-03-20), pages 7365 - 7378, XP055219090, DOI: 10.18632/oncotarget.3629
ZHU, T. ET AL.: "Berberine increases doxorubicin sensitivity by suppressing STAT3 in lung cancer", THE AMERICAN JOURNAL OF CHINESE MEDICINE, vol. 43, no. 7, 2015, pages 1 - 16
ZOU KUN, LI ZHAO, ZHANG YONG, ZHANG HAO-YUE, LI BO, ZHU WEI-LIANG, SHI JI-YE, JIA QI, LI YI-MING: "Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system", ACTA PHARMACOLOGICA SINICA, NATURE PUBLISHING GROUP, GB, vol. 38, no. 2, 1 February 2017 (2017-02-01), GB, pages 157 - 167, XP055782100, ISSN: 1671-4083, DOI: 10.1038/aps.2016.125
Attorney, Agent or Firm:
KIM, Bo-min (KR)
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