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Patent Searching and Data


Title:
COMPOSITION FOR INHIBITING TOXICITY OF NANOPARTICLES AND ENVIRONMENTALLY-DERIVED FINE PARTICLES
Document Type and Number:
WIPO Patent Application WO/2021/029673
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting the toxicity with respect to nanoparticles and fine particles generated from the environment. Since it has been confirmed that a decrease in intracellular ATP, a decrease in cell viability, inflammation-induced morphological changes in cells and cell activation, which are induced by nanoparticles or environmentally-derived fine particles, are inhibited by means of the composition of the present invention, the composition may be utilized as a reducing substance for the toxicity of nanoparticles and fine particles.

Inventors:
LEE GWANG (KR)
SHIN TAE-HWAN (KR)
KANG YUP (KR)
KWAK JONG-YOUNG (KR)
LEE DAYEON (KR)
Application Number:
PCT/KR2020/010687
Publication Date:
February 18, 2021
Filing Date:
August 12, 2020
Export Citation:
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Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K38/06; A23L33/17; A61K8/365; A61K8/64; A61K31/191; A61P39/00; A61Q17/00; A61Q19/00
Foreign References:
KR20150046535A2015-04-30
KR101646617B12016-08-09
Other References:
KWON DA, CHA HEE-JAE, LEE HYESOOK, HONG SU-HYUN, PARK CHEOL, PARK SHIN-HYUNG, KIM GI-YOUNG, KIM SUHKMANN, KIM HEUI-SOO, HWANG HYE-: "Protective Effect of Glutathione against Oxidative Stress-induced Cytotoxicity in RAW 264.7 Macrophages through Activating the Nuclear Factor Erythroid 2-Related Factor-2/Heme Oxygenase-1 Pathway", ANTIOXIDANTS, vol. 8, no. 4, pages 82, XP055780090, DOI: 10.3390/antiox8040082
AKTER MAHMUDA, SIKDER MD. TAJUDDIN, RAHMAN MD. MOSTAFIZUR, ULLAH A.K.M. ATIQUE, HOSSAIN KANIZ FATIMA BINTE, BANIK SUBRATA, HOSOKAW: "A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives", JOURNAL OF ADVANCED RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 9, 1 January 2018 (2018-01-01), AMSTERDAM, NL, pages 1 - 16, XP055780093, ISSN: 2090-1232, DOI: 10.1016/j.jare.2017.10.008
RADU MIHAELA, MUNTEANU MARIA CRISTINA, PETRACHE SORINA, SERBAN ANDREEA IREN, DINU DIANA, HERMENEAN ANCA, SIMA CORNELIA, DINISCHIOT: "Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells INTRODUCTION", ACTA BIOCHIMICA POLONICA, vol. 57, no. 3, pages 355 - 360, XP055780097
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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